Results for Environment
40,772 grants found
Showing 33,321 – 33,340 of 40,772 grants for "Environment"
Elucidating novel mechanisms for pancreatitis through calcineurin signaling
PROJECT SUMMARY. Acute pancreatitis (AP) is an exquisitely painful, life-threatening, public health problem that has substantial morbidity and limited treatment modalities. Our lon...
Spatiotemporal effects and associations between deforestation and alcohol and tobacco use in Indonesia
PROJECT SUMMARY/ABSTRACT Deforestation is a critical global issue that leads to extensive macro-level changes in our environment. While past literature has linked sudden or expansi...
Systemic travel of damaged DNA in photosensitive autoimmune disorders
PROJECT SUMMARY/ABSTRACT The genome in human skin is routinely damaged by ultraviolet (UV) radiation and other environmental genotoxins that are known to induce systemic inflammati...
Dissecting divergent hematopoietic stem and progenitor cell ontogeny
Dissecting divergent hematopoietic stem and progenitor cell ontogeny during development Project Abstract 1 The hematopoietic and immune landscape is complex. The diversity is gener...
Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental Datasets
PROJECT SUMMARY / ABSTRACT. Substance use disorders affect millions of Americans, with substance use often beginning in adolescence. There is a pressing need to identify targets fo...
Innovations in treatment adherence in pediatric eosinophilic esophagitis
PROJECT SUMMARY Medication nonadherence leads to increased morbidity, mortality, and costs the US healthcare system hundreds of billions of dollars annually. While there have been...
Culturally Responsive Education and Teaching Empowerment in Mathematics in Hawaii (CREATE-Math-HI)
The project aims to serve the national need of developing highly effective teachers by enhancing practices to recruit and diversify mathematics educators who are culturally respons...
Collaborative Research: Effects of wind events on circulation and salinity dynamics in a curved estuary
This project builds on observations in the Neuse Estuary (North Carolina) that have been collected previously and expands upon them through 3-d modeling with a widely used model ca...
Singularities and Long Time Dynamics in Models of Fluids and Reactive Processes
This project is composed of two parts. The main objective is the study of mathematical models of fluid motions, and more specifically creation of small-scale structures and singula...
Automatic integrated biomarkers to improve prediction of lung cancer outcomes
PROJECT SUMMARY/ABSTRACT Research. Non-small cell lung cancer (NSCLC) is the world’s deadliest cancer, but patients with NSCLC can have dramatically different outcomes, illuminatin...
A Mixed Methods Analysis of Pediatric Voice Therapy
Voice disorders occur in 6–17% of children, resulting in dysphonia (i.e., altered vocal quality), which has significant negative health, social, emotional, and educational conseque...
A secure analytics platform to study the prognosis of people with HIV in the USA, Canada and Europe and comparative effectiveness of treatment regimens: the Antiretroviral Therapy Cohort Collaboration
PROJECT SUMMARY/ABSTACT The HIV epidemic has changed dramatically since the introduction of effective antiretroviral therapy (ART), which substantially increased the life expectanc...
Mechanisms enabling the oral-to-systemic absorption of a microbially delivered immunomodulatory peptide
PROJECT SUMMARY/ABSTRACT Bioactive peptides, or drugs made of small proteins, are used to treat an increasing number of human diseases. However, the fact that almost no peptide dru...
Elucidating the role of luminal pH in regulating phagosome transport
Project Summary/ Abstract Macrophages capture harmful microbes by engulfing them and forming dynamic organelles called phagosomes. Following internalization, phagosomes undergo a g...
Post-transcriptional mechanisms of direct cardiac reprogramming
Project Summary Heart attacks, or myocardial infarctions (MI), remain a leading cause of death worldwide. As adult human hearts have limited regenerative capacity, cardiomyocytes (...
Relationships between sulcal morphology, neuropathology, and cognition in aging and Alzheimer's disease
Project Summary Large-scale changes in brain structure occur in aging and Alzheimer's Disease (AD) that demonstrate sulcal vulnerability to age-related atrophy and AD-related...
Immersing student health professionals in BME design classrooms
PROJECT SUMMARY The dominant paradigm for clinical engagement during BME design education involves creating educational experiences for students to access clinical settings as a pa...
Mesenchymal cell plasticity and signaling in lung regeneration
PROJECT SUMMARY Regeneration of the lung following severe injury is an imperfect process and frequently leads to permanently altered lung structure and dysplastic cell types. After...
Neural computations of learning, decision-making and memory
Most of our behavior consists of learning about the environment, choosing between options that we learned about, and storing the learning in memory for future use. These processes...
Determining factors of inflammation that support the expansion and function of long-lived effector cell CD8 T cells in a mature memory compartment
PROJECT SUMMARY/ABSTRACT The use of specific pathogen free (SPF) mice has been instrumental in the advancement of immunological research, reducing variability between experiments a...