Results for Environment
40,772 grants found
Showing 33,241 – 33,260 of 40,772 grants for "Environment"
Molecular mechanisms in the mammalian cell nucleus
Abstract/Project Summary My research group strives to gain detailed information about cellular nanoscale structures, dynamics, and molecular mechanisms by designing and applying in...
Research to Advance Connected and Community Health Equity (ReACH Equity)
Project Summary: The UC Davis REsearch to Advance Connected and Community Health Equity (ReACH Equity) Predoctoral Training Program Plan The UC Davis ReACH Equity predoctoral train...
Gamma oscillations in patients with Parkinson’s Disease using chronic invasive brain recording: detection, entrainment, and functional relevance
PROJECT SUMMARY As Parkinson’s disease (PD) progresses, patients develop slowness of movement (bradykinesia), tremor and rigidity. The first-line treatment for PD is the dopamine p...
ProAgio in Pancreatic Cancer
SUMMARY/ABSTRACT Cancer associated fibroblasts and pancreatic stellate cells (PSC/CAF) and abnormal tumor blood vessels are two major factors that contribute to treatment failure....
Repressive Heterochromatin Establishment by Polycomb Complexes
Project Summary The goal of this proposal is to dissect the distinct molecular roles of Polycomb Repressive Complexes 1 and 2 (PRC1&PRC2) and upstream factors in establishing s...
THE FUNCTION OF CASPASE-8 IN CANCER, ANTI-CANCER IMMUNITY, AND CAR-T CELL FUNCTION
Project Summary/Abstract: Caspase-8 is the primary protein that drives the extrinsic apoptotic pathway, and is frequently mutated, contains polymorphisms, or downregulated in vario...
Discovery and functional characterization of somatic variation in intractable focal epilepsy
PROJECT ABSTRACT Focal epilepsy is the most common form of refractory epilepsy. Focal seizures are often associated with malformations of cortical development (MCD) but can also oc...
Neuro-Evolutionary Basis of Vertebrate Social Behavior
Project Summary Sociality involves the ability for animals to live together in cooperative groups, is essential for the survival and development of many species. However, the neura...
Postbaccalaureate Research Education Program (PREP)
PROJECT SUMMARY Effective mentorship is a critical component for academic and career development, particularly for trainees underrepresented (UR) in the biomedical workforce. The M...
Genetic analysis of beneficial bacterial colonization
PARENT AWARD R35GM148385 PROJECT SUMMARY The objective of my laboratory is to characterize how molecular communication between bacteria and their animal hosts leads to specific and...
Leveraging Mobile Technology to Explicate the Role of Emotions in Substance Use Among Trauma-Exposed Community Adults
Project Summary/Abstract The co-occurrence of substance use and trauma is an urgent health priority. The vast majority of U.S. adults (89.7%) have experienced at least one traumati...
Discrete Functions of Basal Forebrain Cholinergic Signaling to Amygdala and Orbitofrontal Cortex in Reversal Learning
This proposal describes a four-year research career development program for an MD/PhD studying the circuit physiology of cognitive flexibility, which has relevance for a largely un...
Modernizing microenvironment monitoring and increasing housing capacity through cutting-edge technologies
PROJECT SUMMARY The goal of this project is to meet the evolving needs of NIH and other research at the Medical University of South Carolina (MUSC), maintain a pathogen-free animal...
Mechanisms of Sex-specific Metabolic Disruption Caused by Organophosphate Flame Retardant Exposure
Project Abstract: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant used to meet federal and state flammability standards of various consumer prod...
Base editing to elucidate RAF regulation and signaling
Project Summary Mitogen activated protein kinase (MAPK) signaling regulates cell growth in normal cells and is frequently overactivated in cancer. Within this pathway, RAF kinases...
CAREER: Multiscale Model for Cell Morphogenesis and Tissue Development in Plant Leaves
This study will improve our understanding about general mechanisms involved in cell morphogenesis. Epidermal cells in plant leaves, especially pavement cells (PCs), exhibit interdi...
Periplasmic biomineralization of semiconductors and semiconductor alloys for living photosensitive biomaterials
NON-TECHNICAL SUMMARY:The periplasm, a confined space inside bacteria, could be used as a platform for new technologies that combine bacteria with semiconductors. These biohybrid s...
Molecular and Developmental Analysis of Holoprosencephaly
Holoprosencephaly (HPE), a common malformation of the forebrain and midface, is caused by failure to define the early rostroventral midline. HPE has a complex etiology, and is asso...
Postdoctoral Fellowship: PRFB: Investigating the biosynthesis and evolution of mesembrine alkaloids in Sceletium
This action funds an NSF Plant Genome Postdoctoral Research Fellowship in Biology for FY 2024. The fellowship supports a research and training plan in a host laboratory for the Fel...
Postdoctoral Fellowship: PRFB: Quantifying single-cell response to phage-induced stresses and high hydrostatic pressure in bacteria.
This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2024, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Envir...