Results for Environment
40,772 grants found
Showing 33,201 – 33,220 of 40,772 grants for "Environment"
Metabolic Mechanisms in Locus Coeruleus Neuron Vulnerability in Neurodegenerative Disease
PROJECT SUMMARY Locus coeruleus (LC) dysfunction and degeneration occurs early in Alzheimer’s Disease (AD). LC degeneration also occurs early in other AD-related neurogenerative di...
Transdisciplinary Research Accelerating Neuropathology Studies and Facilitating Open Research Methods in TBI (TRANSFORM-TBI)
Traumatic brain injury (TBI) is recognized as a modifiable risk factor for neurodegenerative diseases, including Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/A...
Modulation of alcohol sensitivity and alcohol tolerance by exogenous ketones in humans
PROJECT SUMMARY/ABSTRACT Most adults in the United States consume alcohol at some point in their lifetimes. Excessive drinking may elicit detrimental consequences, such as liver ci...
Boosting protein synthesis using antisense oligonucleotides to treat neurodegeneration
PROJECT SUMMARY Brain aging and disease occur alongside the loss of essential proteins and protein functions. For example, thousands of inherited conditions are due to genetic hapl...
CAS:Improving the Activity of Homogeneous Mn Catalysts for the Oxygen Reduction Reaction
With the support of the Chemical Catalysis program in the Division of Chemistry, Charles W. Machan of the University of Virginia is studying the catalytic reduction of dioxygen by...
Determining the nigrostriatal circuit basis of false auditory perceptions.
Project Summary/Abstract Auditory perception can become disrupted in disorders like autism and psychosis. Higher-order auditory pro- cessing occurs in the auditory thalamus and cor...
A surrogate modeling framework for interpreting deep neural networks in functional genomics
Understanding how the complex coordination of many different proteins bind to DNA and RNA provides mechanistic insights into cellular regulatory functions. Recent developments in d...
Superwoman Coping: A multi-level analysis of self-management behaviors and cardiovascular disease risk among Black women with systemic lupus erythematosus
PROJECT SUMMARY/ABSTRACT In the United States, about 90% of those living with systemic lupus erythematosus (SLE) are women and rates of SLE are 2-4 times higher among Black individ...
BRC-BIO: The origin and genetic makeup of rare plants: bridging micro- and macroevolution in the California Floristic Province
This project will examine the origin and genetics of four rare plants in California, a state known for having high biological diversity. In California, there are over 6,000 differe...
Data Science for Diverse Scholars in Down Syndrome Research (DS3)
PROJECT SUMMARY. The mission of the NIH INCLUDE Project is to accelerate research that addresses the critical health and quality of life needs of individuals with Down syndrome (DS...
Upon Solving the Secrets for Lens Transdifferentiation
Abstract Urodele newts are the unrivaled champions of vertebrate tissue regeneration. A greater understanding of the processes which enable their regenerative capabilities could in...
2024 Waterman Award
The US National Science Foundation (NSF) has named Dr. Rebecca Kramer-Bottiglio as one of three recipients of the 2024 Alan T. Waterman Award, the agency's highest honor. This...
HCC: CAREER: Foundational Interaction Research for Manipulating Drones
Small uninhabited aerial vehicles (UAVs) have become a part of everyday human activities like farming, sports, and zoon management. These UAVs have offered new ways to see the worl...
Pseudomonas pathogenesis in the bladder
SUMMARY This proposal will elucidate how an understudied uropathogen – Pseudomonas aeruginosa – establishes acute infection and will determine whether age influences infection esta...
Determining the genetic drivers of ancestry-specific differential penetrance of APOE4 in sporadic Alzheimer’s Disease
PROJECT SUMMARY AND ABSTRACT Alzheimer’s disease (AD) is a heritable and debilitating progressive neurological disease and the most common form of dementia. Among the AD risk loci...
An Engineered Tidemark for Osteochondral Tissue Engineering
Lesions to articular cartilage and underlying subchondral bone eventually lead to osteoarthritis, a debilitating disease with no cure. A successful therapy will need to promote tis...
King's College Robert Noyce Teacher Scholarship Program
The project aims to address the national need evident in the STEM teaching shortage by funding the preparation, retention, and mentorship of high-quality graduates to teach in K-12...
IntBIO Collaborative Research: Assessing drivers of the nitrogen-fixing symbiosis at continental scales
Nitrogen is an essential nutrient for all life on earth. It is also the most abundant element in the atmosphere, but most organisms cannot access it from the air directly. Only cer...
Lung fibrosis impairs tumor immunity and limits immune checkpoint efficacy
PROJECT SUMMARY/ABSTRACT The long-term goal of this proposal is to train the applicant to become an independent, academic physician- scientist studying immune responses against lun...
Gordon Research Conference (GRC) on Signaling by Adhesion Receptors
The Gordon Research Conference (GRC) on Signaling by Adhesion Receptors was established in 2000 and has become the premier meeting on cellular adhesion biology, mechanobiology, and...