Results for Environment
40,772 grants found
Showing 33,061 – 33,080 of 40,772 grants for "Environment"
Pollution and Lung Health in Active Youth (PLAY) at School
PROJECT SUMMARY/ABSTRACT Over 3 million children in the United States attend schools within 100 meters of a major roadway, resulting in significant exposure to traffic-related air...
Cumulative effects of persistent organic pollutants and non-chemical stressors on child development
Project Abstract The prevalence of neurodevelopmental delays in the United States has increased substantially over the last two decades, possibly due to increased prenatal exposure...
The role of nigrostriatal and striatal cell subtype signaling in behavioral impairments related to schizophrenia
Project Summary/Abstract In psychotic disorders, excess nigrostriatal (NS) dopamine signaling is linked to hallucinations, delusions, and disorganized thought—positive symptoms tha...
Studies of Global Signal Transduction
Abstract: Research in my laboratory has centered on the development and application of multi-disciplinary approaches to study signal transduction pathways important in normal physi...
The Role of Selective A3 Adenosine Receptors Activation in Myocardial Protection in donation After Circulatory Death Heart Transplantion
PROJECT SUMMARY/ ABSTRACT: URBAN PROJECT Despite continued expansion in the use of donor hearts following brain death, there remains an unacceptable shortfall in the supply of suit...
Comparative Effectiveness of Sequential Pharmacotherapeutic Strategies and Virtually Delivered Treatment to Optimize Smoking Cessation
PROJECT SUMMARY There is a critical need for treatment approaches that conveniently deliver evidence-based interventions of counseling and pharmacotherapy to a wide range of smoker...
Mechanisms of proinflammatory glial activation in retinal degeneration
Project Summary / Abstract: The goal of this project is to define dysregulation in key immune checkpoints that regulate microglial activation, including TREM2-TYROBP-APOE signaling...
BIOSPACE, Biodiversity from space - optimized grazing and biodiversity conservation with satellite monitoring
Semi-natural grasslands are valuable biotopes in the agricultural landscape, provide habitats for numerous rare plant and animal species and are among the most diverse habitats – b...
Synaptic circuit organization of motor cortex
SUMMARY/ABSTRACT Goal-directed movements of the arms and hands are essential for many activities of daily living. Dysfunction of the cortical areas controlling these behaviors is a...
Bridges to Baccalaureate Training Program at Portland State University
Project Summary/Abstract The mission of B2B PDX Metro is to recruit, train, and mentor students from underrepresented (UR) groups to increase the effectiveness of bridging from com...
CAREER: Transportation Network Maintenance under Climate Change, Resource Uncertainties, and Connectivity
This Early Faculty Career Development (CAREER) project aims to improve transportation network maintenance with a focus on the growing severity and frequency of natural disasters du...
Targeted degradation of KRAS oncoproteins triggers antitumor immunity and abolishes lung tumor
Summary: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. KRAS is the most frequently mutated oncogene in lung adenocarcinoma, the most co...
Metabolic changes that promote adaptation of Listeria monocytogenes to oxidative stress and preserving intracellular redox homeostasis
Project Summary Listeria monocytogenes (LM) is the causative agent of listeriosis, a fatal foodborne infection in humans and animals. Invasive form of listeriosis has a mortality r...
Detecting dynamic fluctuations in emotion, mood, and functioning: A digital phenotyping approach to clinical monitoring in bipolar disorder
Project Summary/Abstract Digital phenotyping, the in-situ quantification of individual-level phenotypes using data from digital devices, is a promising new tool for measuring patte...
Engineered culture platforms to uncover synergies between microenvironmental cues in modulating liver zonation
ABSTRACT Hepatocytes exhibit compartmental (zonated) functions along the sinusoid with as many as 50% of liver genes thought to be zonated. The initiation and progression of severa...
Glial roles in experience-dependent critical period remodeling
Title: Glial roles in experience-dependent critical period remodeling Summary We propose glia actively prune brain circuits to optimize connectivity based on early-life sensory exp...
Iowa-Diversifying Research And Mentorship (iDREAM)
Project Summary/Abstract The future of Neuroscience must include representation of all people; such diversity is crucial to fuel the innovation required to meet current scientific...
Role of the chromatin regulator HMGA1 in KMT2A-rearranged leukemia
PROJECT SUMMARY/ABSTRACT The objective of this project is to elucidate mechanisms underlying HMGA1 proteins in leukemogenesis and therapy resistance in KMT2A-rearranged (KMT2A-r) a...
Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord Injury
PROJECT SUMMARY Candidate and Environment: Dr. Rana’s career objective is to establish an independent research program aimed to develop therapeutic strategies to enhance respirator...
CAREER: Unraveling the evolutionary history of toothed whale acoustic communication
Toothed whales (dolphins, porpoises, and relatives) are not only among the most acoustically specialized groups of vertebrates, but their communication is potentially one of the mo...