Results for Environment
40,772 grants found
Showing 32,961 – 32,980 of 40,772 grants for "Environment"
A Chemical Strategy of Developing Resistance-Proof, Immune-Friendly Drugs
Clever synthetic strategies have been used to develop highly potent drugs such as antibiotics and chemotherapeutic agents, but concurrently bacteria and cancer cells have also deve...
Regulation of ER sheet biogenesis and function
The endoplasmic reticulum (ER) is a universally conserved component of eukaryotic cells.The ER is organized into three morphologically and functionally distinct domains: ER tubules...
Determining the effects of Sox9 on the cell cycle of intestinal stem cells
Project Summary/Abstract The intestinal crypt houses diverse proliferative cells including highly proliferative Transit Amplifying cells, less proliferative active intestinal stem...
Dysregulation of Liver Macrophages in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States.Metastasis is the major cause of mortality for pati...
Regulation of blast cell quiescence by Pten and Tor
Project Summary/Abstract Quiescence is a defining feature of stem cells, which allows them to persist over time without losing developmental potential.Stem cells and other multipot...
Regulation of ER sheet biogenesis and function
The endoplasmic reticulum (ER) is a universally conserved component of eukaryotic cells. The ER is organized into three morphologically and functionally distinct domains: ER tubule...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Regulation of blast cell quiescence by Pten and Tor
Project Summary/Abstract Quiescence is a defining feature of stem cells, which allows them to persist over time without losing developmental potential. Stem cells and other multipo...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Dysregulation of Liver Macrophages in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States. Metastasis is the major cause of mortality for pat...
Privacy-preserving machine learning through secure management of data's lifecycle in distributed systems: REMINDER
The Artificial Intelligence (AI) becomes ubiquitous and leading a technological paradigm shift.Some of the main objectives set out in the United Nations' Sustainable Developme...
Exposure to Per- and Polyfluoroalkyl Substances and Prostate Cancer: Opportunities for Prevention and Early Detection
PROJECT SUMMARY Prostate cancer (CaP) is the leading non-cutaneous cancer in men, accounting for roughly 1 in 5 new cases and 1 in 10 deaths from cancer per year. Few modifiable ri...
Hepatic Priming of CD4+ T cells Directs Effective Hepatitis B Virus Immunity
PROJECT SUMMARY/ABSTRACT Chronic infection with hepatitis B virus (HBV) is a leading global cause of end-stage liver disease and hepatocellular carcinoma; fatal outcomes that can b...
Biodistribution and biological impact assessment of micro-plastics water contaminants using a sensitive and reliable Xenopus experimental platform
This research proposal addresses growing concerns about small plastic debris (0.1µm to 5 mm) or Microplastics (MPs) that have become major pollutants of aquatic ecosystems worldwid...
Mechanistic understanding of role of ATF2 signaling in radiation-induced esophageal cancer
Project Summary/Abstract The objectives of this proposal are to define fundamental mechanisms that drive radiation-induced esophageal squamous cell carcinoma (ESCC). There is compe...
The development of the trade-off between sampling and remembering the visual world
ABSTRACT Imagine baking a croquembouche, a new culinary challenge. How many steps ahead in the recipe will you bother to remember? Of course, you can always refer back to the recip...
Investigating institutional counter-disinformation communications: A case study of the Russia-Ukraine war
Sophisticated foreign disinformation operations have become a key feature of modern military conflicts, whereby systematic information manipulation and disinformation play a leadin...
Heritage and Loss on the West African Coastline: An Historical-Archaeological Study of the Old Apa Site, Badagry, Nigeria
My study will examine the archaeology of the West African coastline using as a case study the Old Apa site in Badagry, Nigeria. Archaeological work has shown that parts of West Afr...
A strategy for broad root disease resistance in barley
Increasing crop yield to feed the world is a major challenge of our century but it is hampered by diseases caused by filamentous plant pathogens. A particular challenge are disease...
An Abstraction-based Technique for Safe Reinforcement Learning
Autonomous agents learning to act in unknown environments have been attracting research interest due to their wider implications for AI, as well as for their applications in comple...