Results for Environment
40,772 grants found
Showing 32,941 – 32,960 of 40,772 grants for "Environment"
Regulation of Endometriotic Lesion Development by NOTCH1
Project Summary Endometriosis is a chronic, estrogen-dependent gynecological disorder affecting 10-15% of women of reproductive age resulting in pelvic pain and infertility. It is...
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
Summary African Americans experience higher rates of alcohol-related sequalae (e.g., cirrhosis, mortality) relative to their European American counterparts.It is thus critical from...
Cognitive flexibility and reward motivation in adolescent cannabis use: An investigation of neurobehavioral mechanisms and intrinsic resting state connectivity.
7.PROJECT SUMMARY: Cannabis use (CU) initiated in adolescence is associated with substantial consequences, from cognitive decline to addiction.While CU may disrupt normal processes...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers.LS is caused by inherited mutations in t...
Mechanisms of stem cell aging that contribute to clonal outgrowth in head and neck tissues
Project Summary/Abstract By the year 2050, it is projected that over 72 million people will be 65-years or older in the United States, representing 20% of the population. This rapi...
Approach Bias Modification for Co-Occurring Cannabis and Alcohol Use among Treatment-Seeking Adolescents
PROJECT SUMMARY/ABSTRACT Alcohol and cannabis are the first and second most commonly used substances among adolescents.Adolescence is a period of considerable development, making t...
Mentoring Patient-Oriented Pharmacoepidemiologic Research in Rheumatic Diseases
PROJECT SUMMARY Rheumatoid arthritis (RA) is a chronic inflammatory arthritis for which there is no known cure.However, with medical breakthroughs in the past few decades, a dozen...
Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative Colitis
PROJECT SUMMARY This overall goal of this mentored patient-oriented research career development award is to improve our understanding of pouchitis and other inflammatory conditions...
Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstruction
With the introduction of reperfusion therapy, mortality from AMI has decreased markedly, from 20% in 1980 to 5% in 2008, but has plateaued despite the fact that our time to reperfu...
Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstruction
With the introduction of reperfusion therapy, mortality from AMI has decreased markedly, from 20% in 1980 to 5% in 2008, but has plateaued despite the fact that our time to reperfu...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer.We have previously conducted genome-wide...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Filtration Media for In-Home PFAS Removal from Drinking Water
Summary Abstract Per- and polyfluoroalkyl substances (PFAS), also commonly known as perfluorinated compounds, are a large family of man-made, globally distributed chemicals that ha...
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa
Africa bears the vast majority (69%) of the world?s current HIV infections with 26 million persons living with HIV (PLHIV).Increased access to antiretroviral therapy (ART) in Afric...
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa
Africa bears the vast majority (69%) of the world’s current HIV infections with 26 million persons living with HIV (PLHIV). Increased access to antiretroviral therapy (ART) in Afri...
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa
Africa bears the vast majority (69%) of the world’s current HIV infections with 26 million persons living with HIV (PLHIV). Increased access to antiretroviral therapy (ART) in Afri...
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa
Africa bears the vast majority (69%) of the world’s current HIV infections with 26 million persons living with HIV (PLHIV). Increased access to antiretroviral therapy (ART) in Afri...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...