Results for Environment
40,772 grants found
Showing 32,901 – 32,920 of 40,772 grants for "Environment"
The role of norovirus capsid flexibility in infection and pathogenesis
Title: The role of norovirus capsid flexibility in infection and pathogenesis Abstract Virus capsids are metastable structures that transition between a stable form in the environm...
Uterine Glucocorticoid Signaling: a Critical Pathway in the Establishment of Pregnancy
Pregnancy loss is a common and devastating event for women and families, and estimates suggest that more than half of all embryos are lost between fertilization and birth.A signifi...
Development and Persistence of Tissue-Level Musculoskeletal Deformity Following Brachial Plexus Birth Injury
PROJECT SUMMARY Brachial plexus birth injury (BPBI) is a traumatic perinatal neuromuscular injury causing muscle paralysis and lifelong arm impairment. Muscle paralysis in these ch...
Elucidating the structural determinants of odor specificity in insect olfactory receptors
Project Summary The sense of smell provides animals with vital information about their environment. At the molecular level, olfactory stimuli consist of thousands of distinct small...
Allogeneic cytotoxic gammadelta T cells for HIV cure immunotherapy
Allogeneic cytotoxic γδ T cells for HIV cure immunotherapy PROJECT SUMMARY HIV Cure strategies based on the “shock and kill” approach require the use of compounds to reactivate HIV...
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
SUMMARY Long non-coding RNAs (lncRNAs) are epigenetic regulators of the chromatin organization supporting cancer cell activities.There is a gap in the literature identifying the ch...
Lipid dysregulation as a mediator of Rett syndrome disease progression
PROJECT SUMMARY Lipid dysregulation is emerging as a critical component of neurodevelopmental disorders, such as Rett syndrome (RTT).RTT is an X-linked dominant disorder caused pri...
Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery disease
PROJECT SUMMARY Chronic ischemia in muscle (skeletal or cardiac) leads to accumulation of lactic acid and other inflammatory metabolites with subsequent drop in interstitial pH. Th...
Effects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers
Project Summary/Abstract: This proposed project focus on quantifying the spatial and temporal diversity in cortical oxygen metabolism and neurovascular coupling, and informing next...
Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery disease
PROJECT SUMMARY Chronic ischemia in muscle (skeletal or cardiac) leads to accumulation of lactic acid and other inflammatory metabolites with subsequent drop in interstitial pH. Th...
Assessing and Addressing Implicit Organizational Bias to Tackle Mental Health Disparities
PROJECT SUMMARY/ABSTRACT Mental health disparities among ethnic minorities have reached crisis proportions in the United States.Although ethnic minorities are more likely to experi...
Assessing and Addressing Implicit Organizational Bias to Tackle Mental Health Disparities
PROJECT SUMMARY/ABSTRACT Mental health disparities among ethnic minorities have reached crisis proportions in the United States. Although ethnic minorities are more likely to exper...
Assessing and Addressing Implicit Organizational Bias to Tackle Mental Health Disparities
PROJECT SUMMARY/ABSTRACT Mental health disparities among ethnic minorities have reached crisis proportions in the United States. Although ethnic minorities are more likely to exper...
Elucidating the structural determinants of odor specificity in insect olfactory receptors
Project Summary The sense of smell provides animals with vital information about their environment.At the molecular level, olfactory stimuli consist of thousands of distinct small...
Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath Tumors
Project Abstract Individuals with neurofibromatosis type 1 (NF1) have an approximately 160-fold increased risk of developing malignant peripheral nerve sheath tumor (MPNST). As a l...
Imaging the metabolic and phagocytic landscape of microglia in Alzheimer’s disease
Imaging the Metabolic and Phagocytic Landscape of Microglia in Alzheimer’s Disease Genome-wide association studies show that some of the strongest genetic risk variants for Alzheim...
It's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12
The G protein-coupled chemokine receptor, CXCR4, and the atypical chemokine receptor, ACKR3, play critical roles in cell migration during immune responses and organ development, th...
Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath Tumors
Project Abstract Individuals with neurofibromatosis type 1 (NF1) have an approximately 160-fold increased risk of developing malignant peripheral nerve sheath tumor (MPNST). As a l...
It's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12
The G protein-coupled chemokine receptor, CXCR4, and the atypical chemokine receptor, ACKR3, play critical roles in cell migration during immune responses and organ development, th...
The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure, function, and behavior
PROJECT SUMMARY Significance: Neural circuit assembly requires activity-dependent refinement of circuit architecture (e.g. plasticity) to produce stereotyped behavior. Neurons are...