Results for Environment
40,772 grants found
Showing 32,821 – 32,840 of 40,772 grants for "Environment"
Cognitive flexibility and reward motivation in adolescent cannabis use: An investigation of neurobehavioral mechanisms and intrinsic resting state connectivity.
7. PROJECT SUMMARY: Cannabis use (CU) initiated in adolescence is associated with substantial consequences, from cognitive decline to addiction. While CU may disrupt normal process...
Mechanisms of Corynebacterium-Dolosigranulum Interactions that Shape Human Nasal Microbiota
The objective unifying our two areas of NIGMS-funded research is to identify molecular mechanisms underlying microbe-microbe and microbe-host interactions involving D. pigrum and n...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Genome-wide mechanisms and dynamics of ATP-dependent chromatin remodeling complexes
PROJECT SUMMARY/ABSTRACT The SWI/SNF family ATP-dependent chromatin remodelers are multi-subunit protein complexes that dynamically position chromosomal nucleosomes to modulate DNA...
POST-TRANSCRIPTIONAL REGULATION OF CELL FATE IN EARLY MAMMALIAN DEVELOPMENT
Post-transcriptional regulation by RNA-binding proteins (RBPs) and microRNAs (miRNAs) orchestrate diverse molecular and cellular mechanisms that pattern early mammalian development...
Passive Assessment of Behavioral Warning Signs for Suicide Risk in Adolescents: An Idiographic Approach
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death among adolescents and the rates have doubled since 2000. The rise in suicide rates is due in part to a failure...
Mentoring Patient-Oriented Pharmacoepidemiologic Research in Rheumatic Diseases
PROJECT SUMMARY Rheumatoid arthritis (RA) is a chronic inflammatory arthritis for which there is no known cure. However, with medical breakthroughs in the past few decades, a dozen...
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
SUMMARY Long non-coding RNAs (lncRNAs) are epigenetic regulators of the chromatin organization supporting cancer cell activities. There is a gap in the literature identifying the c...
U-RISE at Texas State University
Project Summary/Abstract Texas State University (TxState) will implement an Undergraduate Research Training Initiative for Student Enhancement program (U-RISE Tx) to increase the d...
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
Summary African Americans experience higher rates of alcohol-related sequalae (e.g., cirrhosis, mortality) relative to their European American counterparts. It is thus critical fro...
Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis
Abstract Despite the critical importance of the O-glycoprotein apolipoprotein E (APOE) on Alzheimer’s disease (AD) risk, with the APOE4 isoform increasing risk compared to APOE3 an...
Identifying novel networks of candidate Atrial Fibrillation genes in the Drosophila cardiac aging model
Project Summary/Abstract Atrial fibrillation (AF), the most common heart rhythm disorder, is reaching epidemic proportions in the aging population, affecting nearly 33 million peop...
Approaches for AI/ML Readiness for Wildfire Exposures.
PROJECT SUMMARY This application is being submitted in response to the (NOSI) identified as NOT-CA-22-056. Background. The specific aims of the parent grant (RF1AG071024) are to es...
Improving Medication Use and Outcomes in Older Adults with Dementia after Hospitalization: Effectiveness of Medicare Programs
PROJECT SUMMARY/ABSTRACT Hospitalizations and medication problems after discharge are a major risk factor for poor health outcomes in older adults with Alzheimer's disease and...
Using a Rare Disease Model to Explore the Role of FGF21 in Insulin Resistance
Project Summary/Abstract Insulin-mediated pseudoacromegaly (IMPA) is a rare insulin resistance syndrome that is distinct from other insulin resistance syndromes, as it leads to ove...
Adipocyte mitochondrial distress drives the intercommunication between white and brown adipose tissues
Project Summary/Abstract One third of American adults are suffering from obesity, which significantly contributes to the prevalence of many other life-threatening diseases, such as...
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
Summary African Americans experience higher rates of alcohol-related sequalae (e.g., cirrhosis, mortality) relative to their European American counterparts. It is thus critical fro...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility. Predicting the phenotypic effects of mutations is confounded by...
Identifying novel networks of candidate Atrial Fibrillation genes in the Drosophila cardiac aging model
Project Summary/Abstract Atrial fibrillation (AF), the most common heart rhythm disorder, is reaching epidemic proportions in the aging population, affecting nearly 33 million peop...
Neurobiology of loss: role of microglia
Project Summary Psychological loss occurs when one is deprived of something valuable, such as social relationships, physical health, or financial stability. These experiences often...