Results for Environment
40,772 grants found
Showing 32,781 – 32,800 of 40,772 grants for "Environment"
Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis
Abstract Despite the critical importance of the O-glycoprotein apolipoprotein E (APOE) on Alzheimer?s disease (AD) risk, with the APOE4 isoform increasing risk compared to APOE3 an...
Duke Center for Advancement of Child Health (CAtCH)
The Child Health Research Career Development Award (CHRCDA) Program in the Department of Pediatrics at Duke University Medical Center, entitled Duke Center for Advancement of Child...
Role of the Ciliary Protein C2CD3 in Mandibular Skelotogenesis
Project Summary/Abstract Primary cilia are non-motile, microtubule-based organelles that protrude from the cellular membrane to sense the cell?s external environment and to coordin...
Molecular analysis of nuclear lamin assembly
Project Summary Lamin filaments are central structural organizers of the metazoan nucleus.They contribute to nuclear function by controlling nuclear structure, separating the nucle...
Exploring the Role of Drp1 in Colorectal Cancer
Abstract - Exploring the Role of Drp1 in Colorectal Cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Approximately 150,000 new c...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility.Predicting the phenotypic effects of mutations is confounded by p...
Using a Rare Disease Model to Explore the Role of FGF21 in Insulin Resistance
Project Summary/Abstract Insulin-mediated pseudoacromegaly (IMPA) is a rare insulin resistance syndrome that is distinct from other insulin resistance syndromes, as it leads to ove...
Gut Bacteriophage Correspondence with Inflammation and Clinical Dietary Interventions
Project Summary ? NIH F32 Fellowship ? Andrew Brooks ? P.I.Mike Snyder Application Title: Gut Bacteriophage Correspondence with Inflammation and Clinical Dietary Interventions Recu...
POST-TRANSCRIPTIONAL REGULATION OF CELL FATE IN EARLY MAMMALIAN DEVELOPMENT
Post-transcriptional regulation by RNA-binding proteins (RBPs) and microRNAs (miRNAs) orchestrate diverse molecular and cellular mechanisms that pattern early mammalian development...
A Personalized, Patient-Centered Approach to Optimizing Lupus Care
Candidate: April Jorge, MD is an Instructor in Medicine at Harvard Medical School (HMS) and an Assistant in Medicine in the Rheumatology Unit at Massachusetts General Hospital (MGH...
Team-Based Design of Assistive Technology Devices
Project Summary The goal of this proposed educational program is to train and create a biomedical engineering workforce capable of identifying and addressing the assistive technolo...
Mechanisms of Corynebacterium-Dolosigranulum Interactions that Shape Human Nasal Microbiota
The objective unifying our two areas of NIGMS-funded research is to identify molecular mechanisms underlying microbe-microbe and microbe-host interactions involving D. pigrum and n...
U-RISE at Portland State University
The overarching aim of our proposed training program is to provide an integrated experience and pathway for underrepresented undergraduate students who aspire to become independent...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ?65-years, ?1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...
Dissecting Innate Immune Responses to Salmonella Enteritidis
Project Summary and Abstract Salmonella enterica is the leading cause of food-borne hospitalizations in the United States.The Salmonella enterica species includes over 2500 circula...
Genome-wide mechanisms and dynamics of ATP-dependent chromatin remodeling complexes
PROJECT SUMMARY/ABSTRACT The SWI/SNF family ATP-dependent chromatin remodelers are multi-subunit protein complexes that dynamically position chromosomal nucleosomes to modulate DNA...
Defining the mechanisms of kinetoplast DNA assembly by trypanosomal topoisomerase II for therapeutic target development
Project Summary/Abstract Type IIA topoisomerases (topo II) are ubiquitous molecular machines that manage DNA superhelical structure and decatenate DNA entanglements to support crit...
Neurobiology of loss: role of microglia
Project Summary Psychological loss occurs when one is deprived of something valuable, such as social relationships, physical health, or financial stability.These experiences often...
Mechanisms of stem cell aging that contribute to clonal outgrowth in head and neck tissues
Project Summary/Abstract By the year 2050, it is projected that over 72 million people will be 65-years or older in the United States, representing 20% of the population. This rapi...
Defining the mechanisms of kinetoplast DNA assembly by trypanosomal topoisomerase II for therapeutic target development
Project Summary/Abstract Type IIA topoisomerases (topo II) are ubiquitous molecular machines that manage DNA superhelical structure and decatenate DNA entanglements to support crit...