Results for Environment
40,772 grants found
Showing 32,761 – 32,780 of 40,772 grants for "Environment"
Passive Assessment of Behavioral Warning Signs for Suicide Risk in Adolescents: An Idiographic Approach
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death among adolescents and the rates have doubled since 2000.The rise in suicide rates is due in part to a failure...
Exploring the Role of Drp1 in Colorectal Cancer
Abstract - Exploring the Role of Drp1 in Colorectal Cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Approximately 150,000 new c...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility. Predicting the phenotypic effects of mutations is confounded by...
Approach Bias Modification for Co-Occurring Cannabis and Alcohol Use among Treatment-Seeking Adolescents
PROJECT SUMMARY/ABSTRACT Alcohol and cannabis are the first and second most commonly used substances among adolescents. Adolescence is a period of considerable development, making...
Cognitive flexibility and reward motivation in adolescent cannabis use: An investigation of neurobehavioral mechanisms and intrinsic resting state connectivity.
7. PROJECT SUMMARY: Cannabis use (CU) initiated in adolescence is associated with substantial consequences, from cognitive decline to addiction. While CU may disrupt normal process...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers. LS is caused by inherited mutations in...
A Personalized, Patient-Centered Approach to Optimizing Lupus Care
Candidate: April Jorge, MD is an Instructor in Medicine at Harvard Medical School (HMS) and an Assistant in Medicine in the Rheumatology Unit at Massachusetts General Hospital (MGH...
Mechanisms of Corynebacterium-Dolosigranulum Interactions that Shape Human Nasal Microbiota
The objective unifying our two areas of NIGMS-funded research is to identify molecular mechanisms underlying microbe-microbe and microbe-host interactions involving D. pigrum and n...
Using a Rare Disease Model to Explore the Role of FGF21 in Insulin Resistance
Project Summary/Abstract Insulin-mediated pseudoacromegaly (IMPA) is a rare insulin resistance syndrome that is distinct from other insulin resistance syndromes, as it leads to ove...
Regulation of Endometriotic Lesion Development by NOTCH1
Project Summary Endometriosis is a chronic, estrogen-dependent gynecological disorder affecting 10-15% of women of reproductive age resulting in pelvic pain and infertility. It is...
Improving Medication Use and Outcomes in Older Adults with Dementia after Hospitalization: Effectiveness of Medicare Programs
PROJECT SUMMARY/ABSTRACT Hospitalizations and medication problems after discharge are a major risk factor for poor health outcomes in older adults with Alzheimer's disease and...
Identifying novel networks of candidate Atrial Fibrillation genes in the Drosophila cardiac aging model
Project Summary/Abstract Atrial fibrillation (AF), the most common heart rhythm disorder, is reaching epidemic proportions in the aging population, affecting nearly 33 million peop...
Passive Assessment of Behavioral Warning Signs for Suicide Risk in Adolescents: An Idiographic Approach
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death among adolescents and the rates have doubled since 2000.The rise in suicide rates is due in part to a failure...
Team-based Interdisciplinary Cancer Research Training Program
TEAM-BASED INTERDISCIPLINARY CANCER RESEARCH TRAINING PROGRAM PROJECT SUMMARY/ABSTRACT In advancing innovative ways to address complex cancer challenges, there is a growing trend t...
U-RISE at Claflin University through Collaborative Interdisciplinary Mentoring in Biomedical Sciences
7.Project Summary/Abstract Located in Orangeburg, South Carolina, Claflin University (CU), an independent, four-year, co-educational, residential, career-oriented liberal arts univ...
Early career surgeon performance - a patient safety blind spot
Project Summary/Abstract A recent multi-institutional study suggested that graduating general surgery trainees could not independently perform common operations over 20% of the tim...
Identifying tobacco-genetic interactions through study of the aryl hydrocarbon receptor pathway.
Human exposure to environmental toxins such as those in tobacco related products are the leading cause of preventable deaths in the United States, with the greatest effect on morbi...
U-RISE at Texas State University
Project Summary/Abstract Texas State University (TxState) will implement an Undergraduate Research Training Initiative for Student Enhancement program (U-RISE Tx) to increase the d...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Adipocyte mitochondrial distress drives the intercommunication between white and brown adipose tissues
Project Summary/Abstract One third of American adults are suffering from obesity, which significantly contributes to the prevalence of many other life-threatening diseases, such as...