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20,252 grants found
Showing 19,961 – 19,980 of 20,252 grants
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1.MM is preceded by a less life- threating blood condition, which is simila...
Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
PROJECT SUMMARY The activating V600E mutation in the protein kinase BRAF is a well-established driver of human cancer. The effectiveness of current BRAF inhibitors developed to tar...
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
Men are 3-5 times more likely than women to develop and die from bladder cancer (BCa) but the underlying mechanisms of these gender disparities in BCa are poorly understood. This i...
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive impai...
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive impai...
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive impai...
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive impai...
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive impai...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide.SCC prognosis is context-dependent and does not seem to be determined by driver gene somat...
Targeting Atg5 in platinum-resistant ovarian cancer
Abstract Ovarian cancer is the fifth leading cause of cancer-related death in the United States.The standard first line chemotherapy to treat this deadly disease includes platinum...
Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors
Abstract The improvement in breast cancer survival is partially due to improvements in treatments. However, these treatments are not without mild to life-threatening side effects.F...
Redefining hemophagocytic lymphohistiocytosis in hematologic malignancies
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that is increasingly recognized in patients with malignancies (M-HLH).However, nearly early eve...
Cerebrospinal fluid derived circulating tumor DNA as a clinically relevant biomarker in medulloblastoma
PROJECT SUMMARY Medulloblastoma (MB) is among the most common malignant brain tumors in children.Despite advances in multi-modal patient care and understanding of tumor biology, on...
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
Project Summary The anti-angiogenic agent bevacizumab (BEV) is one of the most effective forms of biologic therapy developed thus far for cervical cancer (CC). However, response is...
Investigating Mechanisms of Hyperprogression on Anti-PD-1 Immunotherapy
Abstract The number of cancer patients being treated with checkpoint blockade immunotherapy (CBI) targeting the PD- 1/PD-L1 pathway is increasing dramatically.Recently a novel and...
Genetic analysis of lung cancer susceptibility
Abstract Although tobacco exposure is the major determinant of lung cancer, only about 15% of smokers develop lung cancer.In this study, we seek to identify genetic effects that in...
Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors and lung cancer prognosis
Project Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic drugs. The use of this class of drugs is on the rise.In addition to it...
Improving CAR T cell therapy for brain tumors using immune competent models
PROJECT SUMMARY/ABSTRACT The overall objective of this study is to engineer a potent CAR T cell therapy for high grade glioma (HGG), a subgroup of brain tumors for which outcomes r...
Methods for Mendelian randomization and mediation analysis using integrative genetic and genomic data for breast cancer
Project summary Haoyu Zhang, PhD is a statistician whose ultimate career goal is incorporating advanced causal inference techniques into genetics and biological research in order t...
Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations
PROJECT SUMMARY/ABSTRACT The goal of the proposed research training program is to provide tailored additional training to facilitate successful career development throughout the co...