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20,252 grants found
Showing 19,941 – 19,960 of 20,252 grants
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Chromatin Organization in Glioma Initiation
Project SummaryGlioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relationto its incidence. In the last decade, it h...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC).Disturban...
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC). Disturba...
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC). Disturba...
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC). Disturba...
Molecular mechanisms of NFIB in small cell lung cancer metastasis
PROJECT SUMMARY Most cancer patients do not die from their primary tumor but from their metastases. In spite of the morbidity and mortality associated with metastatic disease, rela...
Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
PROJECT SUMMARY The activating V600E mutation in the protein kinase BRAF is a well-established driver of human cancer. The effectiveness of current BRAF inhibitors developed to tar...
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1. MM is preceded by a less life- threating blood condition, which is simil...
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1. MM is preceded by a less life- threating blood condition, which is simil...
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
Men are 3-5 times more likely than women to develop and die from bladder cancer (BCa) but the underlying mechanisms of these gender disparities in BCa are poorly understood.This is...
Molecular mechanisms of NFIB in small cell lung cancer metastasis
PROJECT SUMMARY Most cancer patients do not die from their primary tumor but from their metastases.In spite of the morbidity and mortality associated with metastatic disease, relat...
Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
PROJECT SUMMARY The activating V600E mutation in the protein kinase BRAF is a well-established driver of human cancer.The effectiveness of current BRAF inhibitors developed to targ...
Investigating the Role of DNMT3A mutations in the initiation and maintenance of myeloid malignancies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive malignancy with a poor prognosis, owing in part to substantial intratumor genetic heterogeneity that allows s...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States.Despite recent advances in treatment, the 5-year survival rate remains poor...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States. Despite recent advances in treatment, the 5-year survival rate remains poo...
Investigating the Role of DNMT3A mutations in the initiation and maintenance of myeloid malignancies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive malignancy with a poor prognosis, owing in part to substantial intratumor genetic heterogeneity that allows s...
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1. MM is preceded by a less life- threating blood condition, which is simil...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States. Despite recent advances in treatment, the 5-year survival rate remains poo...