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20,252 grants found
Showing 19,921 – 19,940 of 20,252 grants
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies.
Summary - A fundamental theme in personalized cancer medicine is to identify specific subgroups of patients, based on molecular biomarkers and/or tumor signatures, which will subse...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
Understanding biased agonism in receptor tyrosine kinases to devise new modalities for their targeting in cancer
PROJECT SUMMARY/ABSTRACT This project takes a unique dynamic view of signaling by receptor tyrosine kinases (RTKs), testing the hypothesis that signaling specificity is kinetically...
Novel dual-targeted inhibitors of EGFR and aurora kinase for lung cancer
PROJECT SUMMARY Small molecule EGFR inhibitors constitute the recommended therapy for EGFR-positive non-small cell lung cancer (NSCLC).Resistance was first reported to EGFR inhibit...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography.Despite widespread use, the benefits of mammography in this ag...
Understanding biased agonism in receptor tyrosine kinases to devise new modalities for their targeting in cancer
PROJECT SUMMARY/ABSTRACT This project takes a unique dynamic view of signaling by receptor tyrosine kinases (RTKs), testing the hypothesis that signaling specificity is kinetically...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography. Despite widespread use, the benefits of mammography in this a...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography. Despite widespread use, the benefits of mammography in this a...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography. Despite widespread use, the benefits of mammography in this a...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Investigating multifactorial beta-catenin activation in hepatocellular cancers
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and lacks molecular- targeted therapies. Activation of Wnt/?-catenin cascade has been...
Chromatin Organization in Glioma Initiation
Project Summary Glioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relation to its incidence.In the last decade, it...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Investigating multifactorial beta-catenin activation in hepatocellular cancers
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and lacks molecular- targeted therapies. Activation of Wnt/β-catenin cascade has been...
Chromatin Organization in Glioma Initiation
Project SummaryGlioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relationto its incidence. In the last decade, it h...