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Showing 19,90119,920 of 20,252 grants

Completed NON-SBIR/STTR RPGS
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
NATIONAL CANCER INSTITUTE Mayo Clinic Rochester United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range o...

$9.98M
USD
Completed NON-SBIR/STTR RPGS
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
NATIONAL CANCER INSTITUTE Mayo Clinic Rochester United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women.The low incidence, high fatality and molecularly broad range of...

$10.71M
USD
Completed TRAINING, INDIVIDUAL
Investigating the role of Eya3 in the regulation of innate immune signaling cascades in Triple Negative Breast Cancer
NATIONAL CANCER INSTITUTE University of Colorado Denver United States 2021 – 2024

PROJECT SUMMARY/ABSTRACT: Triple Negative Breast Cancer (TNBC) is a subtype of breast cancer characterized by low or absent expression of the estrogen receptor and the HER2 growth...

$368K
USD
Completed TRAINING, INDIVIDUAL
An Engineered Nanocarrier Platform for Enhancing Immune Responses to Neoantigen-Targeted Cancer Vaccines
NATIONAL CANCER INSTITUTE Vanderbilt University United States 2021 – 2023

Project Summary Vaccines targeting cancer neoantigens have the potential to enhance the magnitude, function, and duration of an anti-tumor T cell response, offering a promising str...

$269.8K
USD
Completed NON-SBIR/STTR RPGS
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
NATIONAL CANCER INSTITUTE Mayo Clinic Rochester United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range o...

$9.41M
USD
Completed NON-SBIR/STTR RPGS
Rational translation of gold nanoparticle mediated radiosensitization to the clinic
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2021 – 2025

The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (GN...

$6.4M
USD
Active NON-SBIR/STTR RPGS
Rational translation of gold nanoparticle mediated radiosensitization to the clinic
NATIONAL CANCER INSTITUTE University of Texas Hlth Sci Ctr Houston United States 2021 – 2026

The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (GN...

$1.47M
USD
Completed NON-SBIR/STTR RPGS
Molecular Functions of CDK1 in Gastric Tumorigenesis
NATIONAL CANCER INSTITUTE University of Miami School of Medicine United States 2021 – 2025

ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...

$4.54M
USD
Completed NON-SBIR/STTR RPGS
Molecular Functions of CDK1 in Gastric Tumorigenesis
NATIONAL CANCER INSTITUTE University of Miami School of Medicine United States 2021 – 2025

ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide.The 2018 global cancer statistics report indicates an estimated over 1,000,000 new cas...

$4.63M
USD
Completed TRAINING, INDIVIDUAL
The role of differential bone marrow immune landscape in permissive tumor growth in the spine
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2021 – 2023

PROJECT SUMMARY/ABSTRACT Roughly 400,000 people in the U.S. have bone metastases, the vast majority occurring in the spine. Metastases to the spine results in fractures, pain, para...

$724.1K
USD
Completed TRAINING, INDIVIDUAL
The role of differential bone marrow immune landscape in permissive tumor growth in the spine
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2021 – 2023

PROJECT SUMMARY/ABSTRACT Roughly 400,000 people in the U.S. have bone metastases, the vast majority occurring in the spine. Metastases to the spine results in fractures, pain, para...

$742.3K
USD
Completed NON-SBIR/STTR RPGS
Molecular Functions of CDK1 in Gastric Tumorigenesis
NATIONAL CANCER INSTITUTE University of Miami School of Medicine United States 2021 – 2025

ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...

$4.54M
USD
Completed NON-SBIR/STTR RPGS
Molecular Functions of CDK1 in Gastric Tumorigenesis
NATIONAL CANCER INSTITUTE University of Miami School of Medicine United States 2021 – 2025

ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...

$4.4M
USD
Completed TRAINING, INDIVIDUAL
Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis
NATIONAL CANCER INSTITUTE Weill Medical Coll of Cornell Univ United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Metastatic melanoma is the cause of over 80% of skin cancer deaths. Previous work in our lab interrogating the molecular differences between highly and poo...

$517.5K
USD
Completed TRAINING, INDIVIDUAL
Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis
NATIONAL CANCER INSTITUTE Weill Medical Coll of Cornell Univ United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Metastatic melanoma is the cause of over 80% of skin cancer deaths.Previous work in our lab interrogating the molecular differences between highly and poor...

$510.4K
USD
Completed TRAINING, INDIVIDUAL
Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis
NATIONAL CANCER INSTITUTE Weill Medical Coll of Cornell Univ United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Metastatic melanoma is the cause of over 80% of skin cancer deaths. Previous work in our lab interrogating the molecular differences between highly and poo...

$526.9K
USD
Completed TRAINING, INDIVIDUAL
Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis
NATIONAL CANCER INSTITUTE Weill Medical Coll of Cornell Univ United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Metastatic melanoma is the cause of over 80% of skin cancer deaths. Previous work in our lab interrogating the molecular differences between highly and poo...

$539.7K
USD
Completed NON-SBIR/STTR RPGS
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
NATIONAL CANCER INSTITUTE University of Texas Hlth Science Center United States 2021 – 2025

SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis.The disru...

$3.67M
USD
Completed NON-SBIR/STTR RPGS
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
NATIONAL CANCER INSTITUTE University of Texas Hlth Science Center United States 2021 – 2025

SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...

$3.61M
USD
Completed NON-SBIR/STTR RPGS
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
NATIONAL CANCER INSTITUTE University of Texas Hlth Science Center United States 2021 – 2025

SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...

$3.61M
USD