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20,252 grants found
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Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Lipid Metabolism-driven Drug Resistance in Multiple Myeloma
Abstract Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells primarily in the bone marrow and has a 5-year survival rate of only 50%. Obesity increase...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Lipid Metabolism-driven Drug Resistance in Multiple Myeloma
Abstract Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells primarily in the bone marrow and has a 5-year survival rate of only 50%. Obesity increase...
Genetic Predictors of Prostate Cancer Survival
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-21-049.Even though most men diagnosed with prostate cancer wi...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT.Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat).African Ame...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African A...
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
PROJECT SUMMARY The high rate of recurrence and treatment-related mortalities in pediatric acute myeloid leukemia (AML) under- scores the critical need to develop targeted therapie...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkers
One major clinical challenge for diagnosis of recurrent glioblastoma (GBM) is assessment of response to treatment. While standard chemo-radiotherapy improves survival, it also comp...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African A...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkers
One major clinical challenge for diagnosis of recurrent glioblastoma (GBM) is assessment of response to treatment. While standard chemo-radiotherapy improves survival, it also comp...
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
PROJECT SUMMARY The high rate of recurrence and treatment-related mortalities in pediatric acute myeloid leukemia (AML) under- scores the critical need to develop targeted therapie...