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20,252 grants found
Showing 19,821 – 19,840 of 20,252 grants
Characterization of ILEI/LIFR Axis-induced Intracellular Signaling
Project Summary Our lab has previously identified a mechanism of transforming growth factor beta (TGF?)-mediated epithelial-to-mesenchymal transition (EMT) in murine mammary epithe...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
Project Abstract Overview: In 2020, over 276,000 women will be diagnosed with invasive breast cancer, and over 48,000 will die from it. The ultimate goal of this project is to prov...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
NCI Diversity Supplement: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
ABSTRACT A separate Abstract is not requested. This is an NCI Diversity Supplement to Dr. Juan Fueyo-Margareto’s NCI grant, R01 CA256006, titled, “Glioma therapy with oncolytic ade...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Tumor Metabolism and the Microenvironment
ABSTRACT Support is requested for a Keystone Symposia conference entitled Tumor Metabolism and the Microenvironment, organized by Drs. Erik A. Sahai, Alec Kimmelman and Johanna A....
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments.We and others have observed up to 15% of all DMGs to h...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7.Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers,...
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States.Although promising new drugs based on PARP i...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...
A large animal model to elucidate the role of LGR5 stem cells in cancer
Project Summary In the United States, colorectal cancer (CRC) is the 3rd leading cause of cancer death among women and men combined, with of 1 in 20 people being diagnosed with CRC...
A New Strategy to Increase Proteotoxic Cell Death in Hepatocellular Carcinoma
Inhibitors of the ubiquitin proteasome system (UPS, the major pathway that degrades unfolded proteins) increase proteotoxic stress and have clinical success for multiple myeloma bu...
Role of CD36 and diet-derived fatty acids in breast cancer
Abstract Fat is one of the three main nutrients, along with carbohydrate and protein.Fats are important sources of fatty acids (FAs), which are lipids that play a pivotal role in m...
FAST-FNA immune cell profiling in HNSCC
Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue.Curr...