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20,252 grants found
Showing 19,801 – 19,820 of 20,252 grants
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer
ABSTRACT Head and neck cancer is currently treated by concomitant chemotherapy and radiation, but local recurrence and metastatic disease remain a concern. In particular, there is...
Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%. The mainstay of therapy in PDA is chemother...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States. Given the high percentage of cancer patients with co-existing atherosclerosis, t...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Role of phosphate availability in lung cancer invasion and bone metastasis
PROJECT SUMMARY Metastatic dissemination is a leading cause of death from cancer with metastasis to bone represents a particularly poor prognosis. Unfortunately, metastasis to bone...
Development of a tumor-activated IL12 prodrug to treat solid tumors
Project Summary/Abstract: Despite recent advances in cancer immunotherapy, solid tumors remain largely refractory to treatment due to disruption of immune homeostasis by the tumor...
Dysregulation of Liver Macrophages in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States. Metastasis is the major cause of mortality for pat...
Role of phosphate availability in lung cancer invasion and bone metastasis
PROJECT SUMMARY Metastatic dissemination is a leading cause of death from cancer with metastasis to bone represents a particularly poor prognosis. Unfortunately, metastasis to bone...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity. DC depletion abrogates tumor immunity and response to PD1 (αPD1) immunotherapy in many preclinical tu...
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months. Chemotherapy in combination with surgery and radiation may modestly exten...
T cell mechanisms of immunotherapy response in pancreatic ductal adenocarcinoma
Project Summary Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have been largely ineffective for non-immunogenic cancer...
Tracing Intratumoral Cellular Heterogeneity using genetic barcoding in small cell lung cancer
PROJECT SUMMARY Tumors are often highly heterogeneous, with a number of functionally different cells existing within a single tumor, giving some cells the ability to initiate new t...
Improving sleep in gynecologic cancer survivors
PROJECT SUMMARY Sleep disturbance is one of the primary complaints of gynecologic cancer survivors, with more than 80% of survivors reporting sleep difficulties. Sleep disturbance...
Cancer misinformation on social media and its correction
Project Summary The overarching goal of this study is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread.Bel...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling
Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States.HCC is preventable, and it disproportionately affects migrants...