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20,252 grants found
Showing 19,741 – 19,760 of 20,252 grants
Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling
Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States. HCC is preventable, and it disproportionately affects migrants...
Polyunsaturated fatty acids and colorectal tumor risk: a molecular and genetic epidemiology study
PROJECT SUMMARY/ABSTRACT Arachidonic acid, a long-chain ω-6 polyunsaturated fatty acid (PUFA), has been demonstrated to affect carcinogenesis in animal and in vitro studies. The ef...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Development of a tumor-activated IL12 prodrug to treat solid tumors
Project Summary/Abstract: Despite recent advances in cancer immunotherapy, solid tumors remain largely refractory to treatment due to disruption of immune homeostasis by the tumor...
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States. Although promising new drugs based on PARP...
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months. Chemotherapy in combination with surgery and radiation may modestly exten...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments. We and others have observed up to 15% of all DMGs to...
Integrated Training in Quantitative and Experimental Cancer Systems Biology
Project Summary There is an outstanding need for a national cadre of quantitatively sophisticated oncologists, with deep training in both biological aspects of cancer and computati...
Elucidating USP16 function and probing its DUB activity in Down syndrome leukemia
Project Summary / Abstract Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem and progenitor cell (HSPC) disorders with frequent transformation to acute my...
Surgical Multispecialty Access to Research in Residency Training (SMART)
SUMMARY Surgeon-scientists are an underrepresented population in academic medicine, and federally funded surgeon- scientist-led research has been in decline over the past decade. S...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity. DC depletion abrogates tumor immunity and response to PD1 (αPD1) immunotherapy in many preclinical tu...
Understanding affective processing of scientific evidence to promote informed choice for breast cancer screening
Project Summary/Abstract Cancer screening for the right patients at the right level of cancer risk can save lives, but over the last several years many expert groups have de-intens...
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM’s heterogeneity and immunosuppres...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells. MF play a key role in shaping the...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women. Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, a...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies....
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...