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20,252 grants found
Showing 19,721 – 19,740 of 20,252 grants
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells. MF play a key role in shaping the...
Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling
Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States. HCC is preventable, and it disproportionately affects migrants...
Investigation of the Carcinogenic Effects of Bactericidal Antibiotics in the Gut
Project Summary/Abstract Colitis-associated cancer (CAC) refers to the pathological transition from inflammatory bowel disease (IBD) to colorectal cancer (CRC). Burgeoning evidence...
Development of a tumor-activated IL12 prodrug to treat solid tumors
Project Summary/Abstract: Despite recent advances in cancer immunotherapy, solid tumors remain largely refractory to treatment due to disruption of immune homeostasis by the tumor...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States. Although promising new drugs based on PARP...
Investigating TLR-agonist adjuvancy in STING-activating nanoparticle cancer vaccines
Project Summary/Abstract Therapeutic vaccination against melanoma has yet to realize its clinical potential. Several phase III clinical trials assessing efficacy of vaccination aga...
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
Elucidating USP16 function and probing its DUB activity in Down syndrome leukemia
Project Summary / Abstract Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem and progenitor cell (HSPC) disorders with frequent transformation to acute my...
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM’s heterogeneity and immunosuppres...
Portable, Patient-Administered Scalp Cooling Cap to Reduce Provider Burden, Improve Patient Access, and Improve Patient Outcomes for Chemotherapy-Induced Alopecia
PROJECT SUMMARY—Approximately two-thirds of patients undergoing cancer treatment experience hair loss from chemotherapy-induced alopecia (CIA). Patients say CIA is one of the most...
The ontogeny and function of CD8 T cells in lung cancer
PROJECT SUMMARY/ABSTRACT Targeting the immune system to destroy cancer cells using immunotherapy has rapidly emerged as a promising avenue for treating cancer, and has resulted in...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
The ontogeny and function of CD8 T cells in lung cancer
PROJECT SUMMARY/ABSTRACT Targeting the immune system to destroy cancer cells using immunotherapy has rapidly emerged as a promising avenue for treating cancer, and has resulted in...
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
The effect of epigenetic DNA methylation on the progression of HPV-associated precancerous cervical lesions
PROJECT SUMMARY Reducing morbidity and mortality due to invasive cervical cancer (ICC) is a global health priority, which can be accomplished in part by improving the timely detect...
Improving sleep in gynecologic cancer survivors
PROJECT SUMMARY Sleep disturbance is one of the primary complaints of gynecologic cancer survivors, with more than 80% of survivors reporting sleep difficulties. Sleep disturbance...