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20,252 grants found
Showing 19,681 – 19,700 of 20,252 grants
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States. Although promising new drugs based on PARP...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells. MF play a key role in shaping the...
RESISTANCE AND RESPONSE SIGNALING TO PARP1 INHIBITORS IN OVARIAN CANCER
The last twenty years have seen significant progress in ovarian cancer treatment, in particular for the women carrying pathogenic variants in BRCA1 or BRCA2. The foundation for thi...
Neoadjuvant PD-1 blockade in mismatch repair deficient rectal cancer
ABSTRACT Rectal cancer is treated with induction chemotherapy followed by chemoradiationand subsequentsurgery. Most patients who have undergone this sequential treatment approach h...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies....
Investigation of the Carcinogenic Effects of Bactericidal Antibiotics in the Gut
Project Summary/Abstract Colitis-associated cancer (CAC) refers to the pathological transition from inflammatory bowel disease (IBD) to colorectal cancer (CRC). Burgeoning evidence...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits for cancer recovery and risk reduction for futur...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
Improving sleep in gynecologic cancer survivors
PROJECT SUMMARY Sleep disturbance is one of the primary complaints of gynecologic cancer survivors, with more than 80% of survivors reporting sleep difficulties. Sleep disturbance...
Gasdermin E-mediated pyroptosis in promoting antitumor immunity and cancer treatment
Project Summary/Abstract The majority of cancers, which are immunologically “cold” with limited T cell infiltration, show abysmal response rates to immunotherapy. Novel strategies...
Identifying targets for combination therapy with FOLFIRINOX and investigating cell polarity loss as a potential driver of invasion in basal-like PDAC
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal five-year survival rate of 9% even with current treatments. There are two molecular tumor subtype...
Multimodal computational models to stratify ovarian cancer patients
Project Summary/Abstract High-grade serous ovarian cancer (HGSC) is the most lethal gynecologic malignancy, with a five-year survival rate of less than 30% for metastatic disease....
Metabolically improving the generation, function, and persistence of therapeutic T cells for the treatment of cancer
Project Summary Immunotherapy has shifted the paradigm in the understanding and treatment of cancer. Within this arsenal of new treatment strategies, adoptive cell therapy (ACT) ha...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Investigating macrophage-to-tumor mitochondrial transfer
Project Summary Tumor metastasis is the leading cause of cancer related mortalities, yet preventing this malignant phenotype continues to elude scientific investigators. In efforts...
Characterization of ILEI/LIFR Axis-induced Intracellular Signaling
Project Summary Our lab has previously identified a mechanism of transforming growth factor beta (TGFβ)-mediated epithelial-to-mesenchymal transition (EMT) in murine mammary epithe...