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20,252 grants found
Showing 19,641 – 19,660 of 20,252 grants
Development of a tumor-activated IL12 prodrug to treat solid tumors
Project Summary/Abstract: Despite recent advances in cancer immunotherapy, solid tumors remain largely refractory to treatment due to disruption of immune homeostasis by the tumor...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Investigating macrophage-to-tumor mitochondrial transfer
Project Summary Tumor metastasis is the leading cause of cancer related mortalities, yet preventing this malignant phenotype continues to elude scientific investigators.In efforts...
Metabolically improving the generation, function, and persistence of therapeutic T cells for the treatment of cancer
Project Summary Immunotherapy has shifted the paradigm in the understanding and treatment of cancer.Within this arsenal of new treatment strategies, adoptive cell therapy (ACT) has...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Role of cDC2 subsets in host protection and CD4T cell responses in melanoma
Project Summary Despite recent successes, many melanoma patients still fail to respond to immunotherapy and there is a pressing need for identifying novel therapeutic targets.The p...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...
T cell mechanisms of immunotherapy response in pancreatic ductal adenocarcinoma
Project Summary Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have been largely ineffective for non-immunogenic cancer...
Cancer misinformation on social media and its correction
Project Summary The overarching goal of this study is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread. Be...
Tracing Intratumoral Cellular Heterogeneity using genetic barcoding in small cell lung cancer
PROJECT SUMMARY Tumors are often highly heterogeneous, with a number of functionally different cells existing within a single tumor, giving some cells the ability to initiate new t...
The role of cellular senescence in chemotherapy-related cognitive impairment
PROJECT SUMMARY The etiology of chemotherapy-related cognitive impairment (CRCI) is understudied despite the growing clinical awareness of its contribution to patient morbidity. Di...
RNA Polymerase I Associated Factors: Novel Targets in Cancer Therapy
PROJECT SUMMARY/ABSTRACT The regulation of ribosome biogenesis (RB) plays a central role in maintaining cellular homeostasis and supporting cell growth. The rate-limiting step in t...
Investigating macrophage-to-tumor mitochondrial transfer
Project Summary Tumor metastasis is the leading cause of cancer related mortalities, yet preventing this malignant phenotype continues to elude scientific investigators. In efforts...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
The ontogeny and function of CD8 T cells in lung cancer
PROJECT SUMMARY/ABSTRACT Targeting the immune system to destroy cancer cells using immunotherapy has rapidly emerged as a promising avenue for treating cancer, and has resulted in...
Effects of GPCR trafficking on the spatiotemporal control of signaling
Project Summary/Abstract G protein coupled receptors (GPCRs) constitute a family of signaling receptors that regulate essentially every physiological process. Recent studies have b...