Browse All Grants
20,252 grants found
Showing 19,621 – 19,640 of 20,252 grants
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
Project Abstract Overview: In 2020, over 276,000 women will be diagnosed with invasive breast cancer, and over 48,000 will die from it.The ultimate goal of this project is to provi...
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM?s heterogeneity and immunosuppres...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
The effect of epigenetic DNA methylation on the progression of HPV-associated precancerous cervical lesions
PROJECT SUMMARY Reducing morbidity and mortality due to invasive cervical cancer (ICC) is a global health priority, which can be accomplished in part by improving the timely detect...
The Utility of WDR5 WIN Site Inhibitors in Rhabdoid Tumors
PROJECT SUMMARY/ABSTRACT Rhabdoid tumors (RT) are rare and aggressive childhood cancers with exceptionally high rates of mortality. Most children suffering with RT will die within...
Identifying targets for combination therapy with FOLFIRINOX and investigating cell polarity loss as a potential driver of invasion in basal-like PDAC
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal five-year survival rate of 9% even with current treatments.There are two molecular tumor subtypes...
Chemical Rescue of Protein Kinases for Cell Signaling Applications
ABSTRACT This is a new F32 application to develop and apply chemical rescue technology to the functional analysis of protein kinases.Protein kinases regulate virtually every aspect...
Investigating TLR-agonist adjuvancy in STING-activating nanoparticle cancer vaccines
Project Summary/Abstract Therapeutic vaccination against melanoma has yet to realize its clinical potential.Several phase III clinical trials assessing efficacy of vaccination agai...
Effects of GPCR trafficking on the spatiotemporal control of signaling
Project Summary/Abstract G protein coupled receptors (GPCRs) constitute a family of signaling receptors that regulate essentially every physiological process. Recent studies have b...
The role of cellular senescence in chemotherapy-related cognitive impairment
PROJECT SUMMARY The etiology of chemotherapy-related cognitive impairment (CRCI) is understudied despite the growing clinical awareness of its contribution to patient morbidity. Di...
Dysregulation of Liver Macrophages in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States.Metastasis is the major cause of mortality for pati...
Interrogating Immunomodulation for Anti-Metastatic Therapy
PROJECT SUMMARY/ABSTRACT Metastatic disease accounts for 90% of deaths amongst patients with solid tumors, revealing the dire need for new therapies that block metastatic progressi...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity.DC depletion abrogates tumor immunity and response to PD1 (?PD1) immunotherapy in many preclinical tum...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells.MF play a key role in shaping the...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Role of phosphate availability in lung cancer invasion and bone metastasis
PROJECT SUMMARY Metastatic dissemination is a leading cause of death from cancer with metastasis to bone represents a particularly poor prognosis.Unfortunately, metastasis to bone...
Multimodal computational models to stratify ovarian cancer patients
Project Summary/Abstract High-grade serous ovarian cancer (HGSC) is the most lethal gynecologic malignancy, with a five-year survival rate of less than 30% for metastatic disease.O...
Portable, Patient-Administered, Sensor-Enhanced Scalp Cooling Cap and Smartphone App to Reduce Provider Burden, Improve Patient Access, and Improve Patient Outcomes for Chemotherapy-induced Alopecia
PROJECT SUMMARY?Drawing on the experiences of patients and healthcare providers, Cooler Heads Care has engineered a low-cost, portable, sensor-enhanced scalp cooling device and sma...
RNA Polymerase I Associated Factors: Novel Targets in Cancer Therapy
PROJECT SUMMARY/ABSTRACT The regulation of ribosome biogenesis (RB) plays a central role in maintaining cellular homeostasis and supporting cell growth. The rate-limiting step in t...