Browse All Grants
20,252 grants found
Showing 19,601 – 19,620 of 20,252 grants
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months.Chemotherapy in combination with surgery and radiation may modestly extend...
Gasdermin E-mediated pyroptosis in promoting antitumor immunity and cancer treatment
Project Summary/Abstract The majority of cancers, which are immunologically ?cold? with limited T cell infiltration, show abysmal response rates to immunotherapy.Novel strategies t...
The ontogeny and function of CD8 T cells in lung cancer
PROJECT SUMMARY/ABSTRACT Targeting the immune system to destroy cancer cells using immunotherapy has rapidly emerged as a promising avenue for treating cancer, and has resulted in...
Re-purposing beta-blockers to improve chemotherapy response
ABSTRACT Metastatic tumors often develop chemoresistance, which makes chemotherapy ineffective.We have exciting evidence that beta-blockers, which are widely used cardiac drugs, ca...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
A Chemical Strategy of Developing Resistance-Proof, Immune-Friendly Drugs
Clever synthetic strategies have been used to develop highly potent drugs such as antibiotics and chemotherapeutic agents, but concurrently bacteria and cancer cells have also deve...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
Surgical Multispecialty Access to Research in Residency Training (SMART)
SUMMARY Surgeon-scientists are an underrepresented population in academic medicine, and federally funded surgeon- scientist-led research has been in decline over the past decade. S...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
Project Summary The lack of specific targets for the treatment of triple-negative breast cancer (TNBC) is a major challenge, as many TNBCs do not respond to cytotoxic chemotherapie...
Mobile Ecological Momentary Diet Assessment: A Low Burden, Ecologically-Valid Approach to Measuring Dietary Intake in Near-Real Time
ABSTRACT The excessive intake of saturated fat and added sugars has been identified as a leading cause of premature mortality among adults in the U.S. contributing to approximately...
Point-of-care HPV mRNA test for cervical cancer screening in low-resource settings
Abstract: There is a significant need to improve global access to cervical cancer screening. Globally, approximately 570,000 women are diagnosed with and 311,000 women die from cer...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis.There has been growing evidence that macr...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies.I...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...
Control of Commitment Steps in Mammalian Homologous Recombination
Project Summary: ?Control of Commitment Steps in Mammalian Homologous Recombination?The appearance of many cancer cases, especially breast, ovarian, and pancreatic cancer, is linke...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women.Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, an...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8?16 months, and few therapies offer a significant improvement in overall survival.However, immunothera...