Browse All Grants
20,252 grants found
Showing 1,941 – 1,960 of 20,252 grants
Therapeutic targeting of VHL-deficient clear cell renal cell carcinoma
Project Summary/Abstract Synthetic lethality screens hold great promise for cancer therapy since they enable the identification of chemical compounds that selectively target tumor...
The molecular basis of 7SK RNA methylation in non-small cell lung cancer
PROJECT SUMMARY Lung cancer is a leading cause of cancer death in the United States, with non-small cell lung cancer (NSCLC) being the major subtype accounting for approximately 85...
Calcium metabolism and lung cancer preneoplasia
PROJECT SUMMARY/ABSTRACT Lung cancer is the second deadliest cancer. Despite its prevalence and unfavorable consequences, current therapeutic approaches are limited. The proposed s...
A sensitivity analysis framework for generalizing randomized clinical trial results in the presence of unmeasured treatment effect modifiers
ABSTRACT Randomized controlled trials (RCTs) are the gold standard for assessing interventions for preventing and treating cancer, but their external validity is only guaranteed if...
Novel approaches to enrich CAR-T cell Therapy in brain tumors using focused ultrasound
PROJECT SUMMARY Focused Ultrasound (FUS) is a powerful technology now FDA approved for several ablative brain therapies, and has demonstrated an impressive safety and efficacy prof...
Profiling Epitranscriptomic RNA editing in Pediatric Cancer
SUMMARY/ABSTRACT Relapsed pediatric T-cell acute lymphoblastic leukemia (T-ALL) is often refractory to conventional therapy and is associated with a dismal survival rate of less th...
Identifying and examining the effects of source and presentation on responses to electronic cigarette public education messages in young adult vapers and non-vapers
PROJECT SUMMARY E-cigarette use (vaping) in 18-24-year-olds is a public health crisis. It is an urgent public health priority to communicate to young adults about the health harm o...
TAZ-driven Regulation of Tumor Microenvironment in Triple-Negative Breast Cancer
ABSTRACT Breast cancer (BC) is a complex and heterogeneous neoplastic disease with a high incidence and mortality. BC can be divided into clinical, histopathologic, and molecular s...
Regulation of esophageal tumorigenesis by protein adduction
SUMMARY Esophageal adenocarcinoma (EAC) is the most prevalent histological type of esophageal malignancy in the US and many Western nations. This tumor remains deadly as approximat...
Mechanisms of Resistance and Therapeutic Targets in T-LGL Leukemia
ABSTRACT T-cell large granular lymphocytic leukemia (T-LGLL) is an incurable, underdiagnosed proliferation of clonal CD8+ cytotoxic T-lymphocytes that results in severe neutropenia...
Is ERBB4 a Driver of BRAF WT Melanomas?
Combining immune checkpoint inhibitors with BRAF and MEK inhibitors has enabled significant improvements in treating metastatic skin cutaneous melanomas that possess activating mut...
Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumors
Project Summary. Cancer is governed by evolutionary principles whereby sequential changes at the genetic and epigenetic level enable proliferation, immune evasion, drug resistance,...
Learning about the effectiveness of lung cancer screening in real-world target populations
PROJECT SUMMARY/ABSTRACT Even the largest lung cancer screening trial to date, the National Lung Cancer Screening Trial (NLST) is insufficient on its own to answer questions about...
Dissecting Convergent Somatic and Germline Alterations that Mediate the Origins and Evolution of Kidney Cancer
PROJECT SUMMARY Germline pathogenic mutations and common variants have been implicated in the development of clear cell renal cell carcinoma (ccRCC). Similarly, recurrent somatic a...
Comparative Effectiveness of Sequential Pharmacotherapeutic Strategies and Virtually Delivered Treatment to Optimize Smoking Cessation
PROJECT SUMMARY There is a critical need for treatment approaches that conveniently deliver evidence-based interventions of counseling and pharmacotherapy to a wide range of smoker...
Notch ligands as oncogenic drivers and therapeutic targets in T-cell lymphomas
Peripheral T-cell lymphomas (PTCL), derived from mature T cells, are aggressive malignancies for which existing therapies are suboptimal, as the median overall survival of patients...
Control of cancer cachexia via stimulation of resolution of inflammation
PROJECT SUMMARY While cancer cachexia is a devastating syndrome characterized by progressive muscle wasting, inflammation, and metabolic disruption, the underlying mechanisms remai...
CRACD-controlled cell plasticity and small cell lung cancer
PROJECT SUMMARY/ABSTRACT Small cell lung cancer (SCLC) is an extremely deadly cancer, and current chemo/radiation therapies lack durable effects. Immunotherapy with immune checkpoi...
Regulation and tumorigenesis of non-classical RAS oncoproteins - Resubmission
PROJECT SUMMARY Oncoproteins drive tumor development and aggressive growth by dysregulating the signaling pathways involved in cell growth, survival, and proliferation. Targeting o...
Context dependent tumor suppression
Project Summary We have identified a novel mode of autonomous programmed cell death that is controlled by p53 in small cell lung cancer (SCLC) — the most deadly form of lung cancer...