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Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US. Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Aberrant STAT Function in CEBPA-mutant Acute Myeloid Leukemia
ABSTRACT Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloblasts in the bone marrow and blood. Classically, AML is though...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US. Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Mechanistic insights into lysosomal nutrient efflux in cancer
ABSTRACT Many RAS-transformed aggressive cancer cells are able to escape cytotoxic chemotherapy and survive in near-starvation conditions.One adaptation making them hard to kill is...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer.We have previously conducted genome-wide...
FY21 CONSOLIDATED FACILITIES TASK ORDER A
The purpose of this project is to complete the high priority exterior repairs to the Building 578 exterior walls, doors and windows to seal all exterior leaks. Reference Drawing Se...
Mechanistic insights into lysosomal nutrient efflux in cancer
ABSTRACT Many RAS-transformed aggressive cancer cells are able to escape cytotoxic chemotherapy and survive in near-starvation conditions. One adaptation making them hard to kill i...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US.There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS).Research is needed to determine the optimal methods and appro...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...
The Role of Glucose-6-Phosphatase in Hepatocellular Carcinoma
PROJECT SUMMARY Although hepatocellular carcinoma (HCC) is the most common form of liver cancer, there are few therapies that are effective in treating this malignant disease.With...
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US. There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS). Research is needed to determine the optimal methods and appr...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
The Role of Glucose-6-Phosphatase in Hepatocellular Carcinoma
PROJECT SUMMARY Although hepatocellular carcinoma (HCC) is the most common form of liver cancer, there are few therapies that are effective in treating this malignant disease. With...