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Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT.Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology.Our...
Synthetic rocaglates as promising therapeutic agents for aggressive hematological malignancies
Project Summary/Abstract Despite the significant advances in therapy development, a large proportion of hematological malignancies, especially the aggressive types remain incurable...
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Synthetic rocaglates as promising therapeutic agents for aggressive hematological malignancies
Project Summary/Abstract Despite the significant advances in therapy development, a large proportion of hematological malignancies, especially the aggressive types remain incurable...
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018.Treatment with radical prostatectomy (RP), complete surgical excisi...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US.Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Overcoming immune checkpoint inhibition with therapeutic plasma exchange and radiotherapy in melanoma
ABSTRACT PD-1-directed immune checkpoint inhibitors (ICI) have significantly improved survival in metastatic melanoma compared to traditional chemotherapy. Unfortunately, less than...
Patient-derived organoids reveal rectal cancers develop radiosensitivity
The Fearon and Vogelstein multistep cancer progression model of colon cancer defines key genetic changes associated with progression from normal colorectal tissue to early/late ade...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018. Treatment with radical prostatectomy (RP), complete surgical excis...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US. Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Overcoming immune checkpoint inhibition with therapeutic plasma exchange and radiotherapy in melanoma
ABSTRACT PD-1-directed immune checkpoint inhibitors (ICI) have significantly improved survival in metastatic melanoma compared to traditional chemotherapy. Unfortunately, less than...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018. Treatment with radical prostatectomy (RP), complete surgical excis...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
Patient-derived organoids reveal rectal cancers develop radiosensitivity
The Fearon and Vogelstein multistep cancer progression model of colon cancer defines key genetic changes associated with progression from normal colorectal tissue to early/late ade...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018. Treatment with radical prostatectomy (RP), complete surgical excis...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...