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20,252 grants found
Showing 19,521 – 19,540 of 20,252 grants
Integrated radiomic and liquid biopsy monitoring in SWOG S1802: A phase 3 therapeutic trial for metastatic prostate cancer
Abstract Prostate cancer (PC) afflicts more men in the U.S. than any other malignancy and is the second leading cause of cancer death in this population. Recently, new therapies ha...
Vitamin K: Body Pools and Function in Breast Cancer
PROJECT SUMMARY/ABSTRACT This proposal focuses on the divergent effects of the two major dietary forms of vitamin K on breast cancer. K vitamins act as cofactors for gamma-glutamyl...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
Psychosocial Risk in Young Survivors of Early Onset Pediatric Cancer: The Role of Physical and Neurocognitive Late Effects
Despite increased survival,1 over two-thirds of children with cancer experience late effects, such as secondary cancers, sensorimotor deficits, and neurocognitive impairment.2,3 Ps...
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ABSTRACT Genetically modified mouse models of breast cancer have been used for decades as premier basic science tools for mechanistic discovery. However, the successful implementat...
Development of microRNA (miR)-based cell-targeted polymeric nanoparticles for myeloma therapy
Project Abstract Multiple myeloma (MM), a cancer of plasma cells that colonize the bone marrow (BM), remains incurable despite the use of new promising treatment modalities. This i...
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ABSTRACT Genetically modified mouse models of breast cancer have been used for decades as premier basic science tools for mechanistic discovery. However, the successful implementat...
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ABSTRACT Genetically modified mouse models of breast cancer have been used for decades as premier basic science tools for mechanistic discovery.However, the successful implementati...
Nannocystin Reagents to Elucidate the Role of Elongation Factor 1a in Apoptosis
Project Summary Nannocystin reagents will be used to interrogate the role of the protein elongation factor 1A in apoptosis of cancer cells.Nannocystins are small molecule natural p...
Psychosocial Risk in Young Survivors of Early Onset Pediatric Cancer: The Role of Physical and Neurocognitive Late Effects
Despite increased survival,1 over two-thirds of children with cancer experience late effects, such as secondary cancers, sensorimotor deficits, and neurocognitive impairment.2,3 Ps...
Integrated radiomic and liquid biopsy monitoring in SWOG S1802: A phase 3 therapeutic trial for metastatic prostate cancer
Abstract Prostate cancer (PC) afflicts more men in the U.S. than any other malignancy and is the second leading cause of cancer death in this population. Recently, new therapies ha...
Vitamin K: Body Pools and Function in Breast Cancer
PROJECT SUMMARY/ABSTRACT This proposal focuses on the divergent effects of the two major dietary forms of vitamin K on breast cancer.K vitamins act as cofactors for gamma-glutamyl...
Development of microRNA (miR)-based cell-targeted polymeric nanoparticles for myeloma therapy
Project Abstract Multiple myeloma (MM), a cancer of plasma cells that colonize the bone marrow (BM), remains incurable despite the use of new promising treatment modalities.This is...
IN VIVO PHARMACOTYPING OF COMBINATION THERAPY IN PRIMARY BRAIN TUMORS
Lodestone Biomedical?s Immunotherapy Response Indication System (IRIS) interrogates the binding states of functionalized magnetic nanoparticles (fMNPs) localized in biosensor probe...
Vitamin K: Body Pools and Function in Breast Cancer
PROJECT SUMMARY/ABSTRACT This proposal focuses on the divergent effects of the two major dietary forms of vitamin K on breast cancer.K vitamins act as cofactors for gamma-glutamyl...
Psychosocial Risk in Young Survivors of Early Onset Pediatric Cancer: The Moderating Role of Sibling Relationships (Diversity Supplement for D. Garcia)
Despite increased survival,1 over two-thirds of children with cancer experience late effects, such as secondary cancers, sensorimotor deficits, and neurocognitive impairment.2,3 Ps...
Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
ABSTRACT Genetically modified mouse models of breast cancer have been used for decades as premier basic science tools for mechanistic discovery. However, the successful implementat...
Nannocystin Reagents to Elucidate the Role of Elongation Factor 1a in Apoptosis
Project Summary Nannocystin reagents will be used to interrogate the role of the protein elongation factor 1A in apoptosis of cancer cells. Nannocystins are small molecule natural...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
ABSTRACT Immunotherapy is the standard of care and an effective treatment for colorectal cancers with deficient mismatch repair proteins (dMMR). The deficiency contributes to high...
Visualizing cell dormancy in a Her2 Crainbow model of breast cancer metastasis
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029. Dr. Snyder’s OMF R01, “Visualizing tumor heterogenei...