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20,252 grants found
Showing 19,481 – 19,500 of 20,252 grants
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Frederick National Laboratory for Cancer Research (FNLCR) Center for SARS-CoV-2 Serological Sciences
The purpose of the National Cancer Institute?s SARS-CoV-2 Serological Sciences Network (SeroNet) is to study the immune response to COVID-19 by developing and deploying serological...
Frederick National Laboratory for Cancer Research (FNLCR) Center for SARS-CoV-2 Serological Sciences
The purpose of the National Cancer Institute’s SARS-CoV-2 Serological Sciences Network (SeroNet) is to study the immune response to COVID-19 by developing and deploying serological...
Mechanisms of leukemogenesis in Down syndrome
PROJECT SUMMARY This is a competitive renewal of our NCI funded grant to study the contributions of trisomy 21 to hematologic malignancies.Children with Down syndrome (DS), who hav...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
Functional epigenomics of transgenic cellular immunotherapies for cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy with T-cells expressing a transgenic T-cell receptor (TCR) can generate sustained clinical responses in a variety of malignancies. How...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
Functional epigenomics of transgenic cellular immunotherapies for cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy with T-cells expressing a transgenic T-cell receptor (TCR) can generate sustained clinical responses in a variety of malignancies. How...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
Functional epigenomics of transgenic cellular immunotherapies for cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy with T-cells expressing a transgenic T-cell receptor (TCR) can generate sustained clinical responses in a variety of malignancies. How...
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa) Study Project Summary The incidence of breast cancer in low and middle-income countries (LMIC) is...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa) Study Project Summary The incidence of breast cancer in low and middle-income countries (LMIC) is...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a s...
Functional epigenomics of transgenic cellular immunotherapies for cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy with T-cells expressing a transgenic T-cell receptor (TCR) can generate sustained clinical responses in a variety of malignancies. How...
Quantitative top-down proteomics of human colorectal cancer cells and tumors
Project Summary It has been estimated that 145,600 people were diagnosed with colorectal cancer (CRC) and 51,020 deaths were predicted due to this disease in 2019 (https://seer.can...