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20,252 grants found
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Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors.Investigations of the therapeutic relevance of STING agonist...
Genetic code expansion to enable the development of short, diverse peptide libraries
Project Summary Many intracellular cancer targets involve protein-protein interactions that are ?undruggable? because the binding surfaces are too large and featureless to be block...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (T...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Mapping Single Extracellular Vesicles to Parent Cells for Immunotherapy Monitoring
This proposal aims to develop an ultra-high sensitive platform that can map cell and extracellular vesicle (EV) molecular information at the single particle level, and apply it to...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis.CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone.Factors that epigenetically silence an HCC tumor suppressor gen...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression.In fact, our analysis of the cancer genome atlas (TC...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Deciphering and targeting a non-genetic driver pathway in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) accounts for nearly 31,000 deaths annually in the United States alone. Factors that epigenetically silence an HCC tumor suppressor ge...
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (T...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
CRC is the third leading cause of tumor-related deaths attributed to vital organ metastasis. CRC patient survival is highly dependent on the cancer staging at the time of diagnosis...
Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer
Despite advances in colorectal cancer (CRC) treatment and early detection, the burden of CRC on African Americans (AAs) remains high. AAs have the highest incidence of CRC among al...