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20,252 grants found
Showing 19,441 – 19,460 of 20,252 grants
Elucidating the Role of Binding Kinetics in the Development of Abl Kinase Drug Resistance
PROJECT SUMMARY The development of small molecule inhibitors has revolutionized targeted therapeutics, especially in the field of protein kinases. However, pharmaceutical developme...
Genetic code expansion to enable the development of short, diverse peptide libraries
Project Summary Many intracellular cancer targets involve protein-protein interactions that are “undruggable” because the binding surfaces are too large and featureless to be block...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Chemoprevention of lung cancer with the β-blocker carvedilol
Abstract Lung cancer is the leading cause of cancer-related death for both men and women.Chronic exposure to carcinogens that are present in tobacco smoking or air pollution is a k...
Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic population
ABSTRACT Pancreatic cancer is a highly lethal malignancy that has a very poor prognosis in the United States. It has a 5- year survival rate of only 9% and is projected to become t...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase.Tyrosine kinase inhibitors (TK...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity.While multiple mechanisms underlying this cardiotoxi...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Chemoprevention of lung cancer with the β-blocker carvedilol
Abstract Lung cancer is the leading cause of cancer-related death for both men and women. Chronic exposure to carcinogens that are present in tobacco smoking or air pollution is a...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (T...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic population
ABSTRACT Pancreatic cancer is a highly lethal malignancy that has a very poor prognosis in the United States. It has a 5- year survival rate of only 9% and is projected to become t...
Biopsy Tract Sealing Device with Magnetic Resonance and X-Ray Image Contrast
PROJECT SUMMARY When cancer is suspected in a patient, the tissue in question must be removed and analyzed. This procedure is called a biopsy and is a crucial step in early detecti...
Leukemia stem cell regulation and resistance
PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (T...
Neutral sphingomyelinase-2 as a mediator of Doxorubicin-induced cardiotoxicity
ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotox...
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy
Summary: The exquisite specificity, amplitude, and quality of T cells govern tumor initiation, progression, and responses to therapy.Two of the most revolutionary and promising imm...
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Stimulator of interferon genes (STING) is an emerging target for the treatment of solid tumors. Investigations of the therapeutic relevance of STING agonis...