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20,252 grants found
Showing 19,421 – 19,440 of 20,252 grants
Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer
ABSTRACT Few risk-eligible women agree to standard endocrine interventions for breast cancer risk reduction due to fear of side effects combined with incomplete efficacy and lack o...
Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer
ABSTRACT Few risk-eligible women agree to standard endocrine interventions for breast cancer risk reduction due to fear of side effects combined with incomplete efficacy and lack o...
THIS IS A REQUIREMENT TO PROVIDE SUPPORT FOR COMMUNICATIONS TO A BROADER AUDIENCE INCLUDING SUPPORT FOR CANCER.GOV, NCI-WIDE COMMUNICATION-BASED INITI
The Division of Cancer Control and Population Sciences (DCCPS) supports web-based, online, electronic and other communication and education efforts as part of its mission.These com...
TIM-1 blocking mAbs for the prevention of graft-versus-host disease in hematopoietic stem cell transplantation patients
PROJECT SUMMARY Graft-versus-host disease (GvHD) is the major complication of hematopoietic stem cell transplantation (HSCT), causing significant morbidity and mortality in patient...
Using Targeted Lipid Nanoparticles to Deliver Chemotherapeutic Agents against Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic cancer continues to be a devastating disease with less than 10% 5-year survival. Pancreatic cancer is aggressive and there are no good tools for...
PRODUCTION OF A CGMP BATCH OF TRIAPINE INJECTION
The aim of the contract to manufacture Drug Product (Novobiocin is Capsule and Triapine is Injectable)
Pre-Meeting Planning Activities for Cancer Intervention and Surveillance Modeling Network (CISNET)
Support to the NCI from Scientific Consulting Group for Pre-Meeting Planning Activities for Cancer Intervention and Surveillance Modeling Network (CISNET).
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
Summary- The inability to clinically treat tumor metastasis is responsible for the majority of cancer patient deaths.Cell migration is a pivotal step in the metastatic disseminatio...
Adrenergic signaling inhibition to enhance the immunogenicity of the ovarian tumor microenvironment prior to PD-1 checkpoint therapy
PROJECT SUMMARY There is growing evidence that links chronic stress to ovarian cancer progression.Cancer diagnosis, chemotherapy, and other traumatic life events can lead to altere...
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
PROJECT SUMMARY Lung adenocarcinoma (LUAD) is the most common cancer diagnosed in lifetime smokers of whom there are more than 90 million in the United States. Smokers with LUAD fr...
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
PROJECT SUMMARY Lung adenocarcinoma (LUAD) is the most common cancer diagnosed in lifetime smokers of whom there are more than 90 million in the United States. Smokers with LUAD fr...
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
PROJECT SUMMARY Lung adenocarcinoma (LUAD) is the most common cancer diagnosed in lifetime smokers of whom there are more than 90 million in the United States. Smokers with LUAD fr...
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
PROJECT SUMMARY Lung adenocarcinoma (LUAD) is the most common cancer diagnosed in lifetime smokers of whom there are more than 90 million in the United States. Smokers with LUAD fr...
Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma
Project Summary Drugs that inhibit Bcl2-family survival proteins promise to change the landscape of cancer care.Cancers activate stress signals in the form of BH3-domain proteins l...
Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma
Project Summary Drugs that inhibit Bcl2-family survival proteins promise to change the landscape of cancer care. Cancers activate stress signals in the form of BH3-domain proteins...
Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma
Project Summary Drugs that inhibit Bcl2-family survival proteins promise to change the landscape of cancer care. Cancers activate stress signals in the form of BH3-domain proteins...
Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma
Project Summary Drugs that inhibit Bcl2-family survival proteins promise to change the landscape of cancer care. Cancers activate stress signals in the form of BH3-domain proteins...
Elucidating the Role of Binding Kinetics in the Development of Abl Kinase Drug Resistance
PROJECT SUMMARY The development of small molecule inhibitors has revolutionized targeted therapeutics, especially in the field of protein kinases.However, pharmaceutical developmen...
Elucidating the Role of Binding Kinetics in the Development of Abl Kinase Drug Resistance
PROJECT SUMMARY The development of small molecule inhibitors has revolutionized targeted therapeutics, especially in the field of protein kinases. However, pharmaceutical developme...
Elucidating the Role of Binding Kinetics in the Development of Abl Kinase Drug Resistance
PROJECT SUMMARY The development of small molecule inhibitors has revolutionized targeted therapeutics, especially in the field of protein kinases. However, pharmaceutical developme...