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20,252 grants found
Showing 19,401 – 19,420 of 20,252 grants
Characterizing genetic modifiers in tumor burden of Tuberous Sclerosis Complex
PROJECT SUMMARY DNA methylation is a key epigenetic regulator of gene expression and is essential for embryonic development and cell differentiation.Aberrant DNA methylation patter...
Identifying the pathways that drive progression of the MPNs to AML
PROJECT SUMMARY The myeloproliferative neoplasms (MPNs), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are closely related clonal hematopoi...
Supernumerary Centrosomes and Cell Proliferation
PROJECT SUMMARY The centriole is a conserved organelle of metazoans that is found at the core of microtubule organizing centers, centrosomes, and at the base of cilia and flagellae...
Anxa2 drives the function of immune suppressive neutrophils in lung cancer
ABSTRACT Although immune checkpoint inhibitor (ICI) therapy has been a tremendous clinical success, just ~20% of non- small cell lung cancer (NSCLC) patients respond to anti-PD1/PD...
Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axis
The overall 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) is less than 50%, and ~75% of human HNSCC cases have mutations in the tumor suppress...
COG NCTN Network Group Operations Center
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically.T...
Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling
ABSTRACT The tumor ecosystem plays a critical role in tumor development, progression and therapeutic response. Previous studies have utilized dissociative and single-cell omics tec...
Understanding PD-L1/L2 protein regulation, detection and signaling to predict melanoma therapeutic sensitivity
PROJECT SUMMARY/ABSTRACT Modulators and effectors of anti-PD-1 responsiveness in cancer include T cell infiltration, an immune- suppressive microenvironment, tumor mutational burde...
Dissecting and Targeting RB1-Mutant Osteosarcoma
PROJECT SUMMARY/ABSTRACT Bone cancer is one of the most common primary malignancies in children and adolescents. Osteosarcoma comprises almost 60% of the common histological subtyp...
Modifiable Factors Associated with Financial Burden: Improving Health Insurance Literacy
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-21-055.The goal of the parent grant, Facilitated Oncology, R37CA255875...
Development of a combined ARFI/SWEI ultrasound elasticity imaging system for targeted prostate biopsy guidance
ABSTRACT Prostate cancer is the most common cancer among men in the United States, and early detection is crucial for effective treatment or management. Following an initial screen...
Pathogenetic roles of USO1 in leukemogenesis
PROJECT SUMMARY B-acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. The protein USO1 is specifically overexpressed in B-acute lymphoblastic leukemia (...
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancer
Triple negative breast cancers (TNBCs) do not express estrogen receptor-α (ERα), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2), and therefore, none...
Role of LSD1 in Triple Negative Breast Cancer Development and Therapeutic Response
PROJECT SUMMARY/ABSTRACT Breast cancer (BC) is the most common cancer and the second leading cause of cancer death in American women. About 10-20% of breast cancers are triple-nega...
Support for the Central Data Collection Center (CDCC)
The Contractor, Westat conducts participant retention activities, as well as passive data collection for approximately 155,000 participants in the National Cancer Institute?s Prost...
Support for the Central Data Collection Center (CDCC)
The Contractor, Westat conducts participant retention activities, as well as passive data collection for approximately 155,000 participants in the National Cancer Institute’s Prost...
Support for the Central Data Collection Center (CDCC)
The Contractor, Westat conducts participant retention activities, as well as passive data collection for approximately 155,000 participants in the National Cancer Institute’s Prost...
CGMP RE-SUPPLY OF HPV 16L1/16RG1
The purpose of this task order is to re-supply recombinant human papillomavirus type 16 chimeric L1/L2 virus-like particles (VLPs) for use as a vaccine (HPV16L1/16RG1 VLP vaccine)...
Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer
ABSTRACT Few risk-eligible women agree to standard endocrine interventions for breast cancer risk reduction due to fear of side effects combined with incomplete efficacy and lack o...
Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer
ABSTRACT Few risk-eligible women agree to standard endocrine interventions for breast cancer risk reduction due to fear of side effects combined with incomplete efficacy and lack o...