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20,252 grants found
Showing 19,381 – 19,400 of 20,252 grants
Platelet Serine/Threonine Phosphatases in Cancer Pathophysiology
The five year survival rate for lung cancer is ~20% despite improved screening methods and advances in treatment. Tumor metastasis is one of the major causes of death in cancer pat...
A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells
Abstract/Summary Chemotherapy and radiation can induce breast tumors to enter a prolonged state of growth arrest with characteristics of senescence. A senescent-like state is also...
Multilevel investigation of uncertain and reclassified genomic variants in clinical oncology
PROJECT SUMMARY/ABSTRACT The overarching goal of this award is to prepare the applicant for an independent, sustained program of research that incorporates psychosocial, behavioral...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why...
Reposition and Optimization of Deferiprone for Breast Cancer Therapy
Parent Grant Summary and Specific Aims In 2020 there will be ~ 276,480 estimated new cases of invasive breast cancer (BCa) among women in the US, causing an estimated ~ 42,170 deat...
Multilevel investigation of uncertain and reclassified genomic variants in clinical oncology
PROJECT SUMMARY/ABSTRACT The overarching goal of this award is to prepare the applicant for an independent, sustained program of research that incorporates psychosocial, behavioral...
Novel multipronged Immunovirotherapy Approach for GBM Treatment
Project Summary Glioblastoma (GBM) prognosis remains dismal with a median survival of 16-18 months despite the use of multimodality treatment.Immunotherapy attempts have been unsuc...
TRPV1 nociceptors in oral carcinogenesis and pain
Project Summary Oral cancer pain is more severe than all other cancers. Patients with metastatic oral cancer experience the greatest pain. Oral cancers activate neurons and produce...
The Unique Roles of Tumor-Specific Th9 Cells for Solid Tumor Eradication
Project Summary Our early studies have characterized IL-9-producing CD4+ T helper (Th9) cells as an antitumor T cell subset.Recently, we also revealed Th9 cells as a novel T cell p...
Clinical Translation of Near Infrared Nerve-Specific Fluorophores for Nerve-sparing Prostatectomy
PROJECT SUMMARY Iatrogenic nerve injury is one of the most feared complications of surgery. Nerves are critically important to the function of most tissues and nerve injury can lea...
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
Abstract Despite major gains in smoking cessation treatment, over half of recently quit smokers will relapse within the first year.Two systematic reviews of relapse prevention stud...
Dissecting and Targeting RB1-Mutant Osteosarcoma
PROJECT SUMMARY/ABSTRACT Bone cancer is one of the most common primary malignancies in children and adolescents. Osteosarcoma comprises almost 60% of the common histological subtyp...
Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
PROJECT SUMMARY Multiple myeloma (MM) is a devastating clonal plasma cell (cPC) malignancy responsible for over 13,000 deaths in the US per year.It is always preceded by pre-malign...
The ASPIRES Study: Activating Cancer Survivors and their Primary Care Providers to Increase Colorectal Cancer Screening
Project Summary Childhood cancer survivors treated with abdominal or pelvic radiotherapy (RT) are almost four times more likely to develop colorectal cancer (CRC) compared to the g...
THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS
ABSTRACT Metastasis, the primary cause of breast cancer-related mortality, is a multistep process culminating with the formation of tumor foci within distant organs.However, only a...
Role of Sirt2 in T Cell Metabolism
PROJECT SUMMARY Metabolism is a key driver of T cell functions, and the switch from oxidative-phosphorylation to aerobic glycolysis is a hallmark of T cell activation.Unfortunately...
A transformative drug discovery platform for allosteric kinase inhibitors
Project Summary The University of Minnesota (UMN) and Photonic Pharma (PP) a Minnesota-based drug discovery start-up, have partnered to optimize, field-test, and deploy at industri...
Longitudinal investigation of sociocultural and behavioral influences on symptom management, biological response, and functioning between Chinese and White breast cancer survivors.
PROJECT SUMMARY The number of US cancer survivors is growing rapidly, including a significant number of Chinese Americans (CA), a group with an annual breast cancer growth rate of...
Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy
PROJECT SUMMARY/ABSTRACT The MMPs have long been recognized as potential targets for cancer therapy, but drugs developed to target these enzymes have been unsuccessful. A primary r...
Determinants of Liver Metastasis
Project Summary/Abstract. Non-alcoholic fatty liver disease can make the liver permissive to liver metastasis.Patients taking an androgen signaling inhibitor, such as enzalutamide...