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20,252 grants found
Showing 19,361 – 19,380 of 20,252 grants
Supernumerary Centrosomes and Cell Proliferation
PROJECT SUMMARY The centriole is a conserved organelle of metazoans that is found at the core of microtubule organizing centers, centrosomes, and at the base of cilia and flagellae...
The Mitochondrial Calcium Uniporter in Pancreatic Cancer Development, Metastasis, and Treatment
Summary: Pancreatic adenocarcinoma (PDAC) is a particularly lethal form of cancer which kills over 40,000 Americans every year. PDAC is most often diagnosed when disease is advance...
Neoadjuvant Immunotherapy with Intratumoral CPG and PD-1 Blockade in Melanoma
PROJECT SUMMARY ABSTRACT High-risk resectable melanoma patients (MPs) with clinically detectable stage III with or without in-transit metastases have high-risk relapse1. Neoadjuvan...
Chemical Proteomic Identification of Druggable Oncogenic Transcription Factors
Project Summary Advances in human genetics have identified +400 genes that when amplified or mutated promote tumorigenesis. While there has been huge success in developing drugs fo...
Engineering Hybrid SynNotch CAR Receptors to Enhance Cell Therapies for Cancer
Chimeric Antigen T Cell (CAR-T) therapies, which redirect a patient’s own T cells towards their cancer, are very promising therapies for difficult to treat and refractory cancers....
Lactate production by tumor associated macrophages promotes tumorigenesis
ABSTRACT Tumor-associated macrophages (TAMs) are the most prevalent immune cell in the tumor microenvironment. TAMs adopt an M2-like phenotype that supports angiogenesis, attenuate...
Reposition and Optimization of Deferiprone for Breast Cancer Therapy
Project Summary/Abstract: In 2020 there will be ~ 276,480 estimated new cases of invasive breast cancer (BCa) among women in the US, causing an estimated ~ 42,170 deaths. Two commo...
Role of Sirt2 in T Cell Metabolism
PROJECT SUMMARY Metabolism is a key driver of T cell functions, and the switch from oxidative-phosphorylation to aerobic glycolysis is a hallmark of T cell activation. Unfortunatel...
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization
Clinical radiation therapy is a noninvasive means to mitigate cancer progression, which is prescribed for more than 50% of prostate cancer patients. Development of radiation techno...
Technology Facilitated Behavioral Intervention for Depression among Diverse Patients in Ambulatory Oncology
AbstractDepressionis one of the most common psychological comorbidities experienced throughout the cancercontinuum. Elevated depressive symptoms in oncology patients is a major con...
Identifying the Role of Tumor Cell Intrinsic DNMT1 in Anti-Tumor Immunity in Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related death in the United States. The five-year survival rate of less than...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why...
Diversity Supplement Ifediora: Image-based models of tumor-immune dynamics in glioblastoma
Abstract Glioblastoma Multiforme (GBM) is the most common of all gliomas with a median survival 14-18 months, despite aggressive treatment regimens. However, glioma is a disease th...
Tumor Organoid-Mediated Drug Testing and Clonality Analysis in Peritoneal Surface Disease of Intestinal Origin
Project Summary The overarching goal of this project is to develop a tumor organoid-based drug screening platform that quantifies the differential drug responsiveness of tumor clon...
Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
Abstract: The Hippo pathway is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control,...
Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity
PROJECT SUMMARY/ABSTRACT The candidate for this NCI Career Development Award is Max Jan, MD, PhD, who has completed clinical training in molecular genetic pathology and is a curren...
BIOSPECIMEN PROCESSING CENTER (BPC) - EARLY ONSET MALIGNANCIES INITIATIVE
This Task Order provides support to the Early Onset Malignancies Initiative (EOMI).The EOMI is a collaborative initiative between CCG and the Division of Cancer Prevention’s NCI Co...
Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
PROJECT SUMMARY Chromatin-based DNA damage response (DDR) pathway is fundamental for protecting cells from genome instability, which is a hallmark of cancer. The DDR pathway is tig...
Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.
PROJECT SUMMARY Most children treated for cancer in the US will achieve long-term survival, and survivorship presents unique challenges for this growing population. Pediatric brain...
Development of a combined ARFI/SWEI ultrasound elasticity imaging system for targeted prostate biopsy guidance
ABSTRACT Prostate cancer is the most common cancer among men in the United States, and early detection is crucial for effective treatment or management. Following an initial screen...