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20,252 grants found
Showing 19,341 – 19,360 of 20,252 grants
THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS
ABSTRACT Metastasis, the primary cause of breast cancer-related mortality, is a multistep process culminating with the formation of tumor foci within distant organs. However, only...
Platelet Serine/Threonine Phosphatases in Cancer Pathophysiology
The five year survival rate for lung cancer is ~20% despite improved screening methods and advances in treatment. Tumor metastasis is one of the major causes of death in cancer pat...
Covalent Protein Binders for Cancer Research and Therapy
Protein-protein interactions are involved in a broad range of cell function and signaling. Various protein binders have been developed to detect or modulate such interactions for r...
Understanding the impact of the Affordable Care Act on cancer treatment and outcomes for adolescents and young adults (AYA)
Adolescents and young adults (AYAs; diagnosed with cancer at ages 15-39-years) have lagged in improvements in cancer survival seen among younger and older populations. A major barr...
Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices
Project Summary Lung and triple-negative breast cancers (TNBCs) are leading causes of cancer-related deaths in the U.S. This high mortality rate is largely due to their propensity...
Mechanisms of translational output control in pancreatic cancer
PROJECT SUMMARY My long-term career goal is to lead a productive academic research group, promoting science by conducting impactful cancer biology research and mentoring the next g...
Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity
PROJECT SUMMARY/ABSTRACT The candidate for this NCI Career Development Award is Max Jan, MD, PhD, who has completed clinical training in molecular genetic pathology and is a curren...
Extracorporeal Filtration of Thermosensitive Liposomes
PROJECT SUMMARY/ABSTRACT This project will develop a device and perform proof-of-concept studies in a rodent tumor model. The device will remove the chemotherapy agent Doxorubicin...
TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity
ABSTRACT Spontaneous T cell pressure against an evolving tumor is a conserved mechanism of anti-tumor immune control. On the other hand, immune therapies directed to alleviate para...
Targeting Serine Auxotrophy in Luminal Breast Cancer
PROJECT SUMMARY/ABSTRACT A major challenge of targeting metabolism for cancer therapy is pathway redundancy, where multiple sources of critical nutrients can diminish the effects o...
Prostate Cancer Radio-Pathomics for Differentiating Clinically Significant Disease
Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancer, affecting one in seven men. Even when treated with a radical prostatectomy, historically about 20% of...
Anti-tumor potential of temperature-sensitive p53 mutants
The p53 tumor suppressor is frequently inactivated by mutations in cancer. Most p53 point mutations are located in the DNA binding domain that prevent folding or disrupt the DNA bi...
Image-guided Interventional Combination Liver Cancer Immunotherapy
PROJECT SUMMARY For clinical application, a critical remaining hurdle for natural killer (NK) cell-based adoptive transfer immunotherapy (ATI) is the inadequate homing efficiency o...
Targeting Serine Auxotrophy in Luminal Breast Cancer
PROJECT SUMMARY/ABSTRACT A major challenge of targeting metabolism for cancer therapy is pathway redundancy, where multiple sources of critical nutrients can diminish the effects o...
Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model
PROJECT SUMMARY/ABSTRACT Radiation plays a central role in the management of the most lethal central nervous system malignancy, glioblastoma (GBM), yet local control rates, and hen...
Investigating a Wnt-telomere feedback loop in the colorectal adenoma-carcinoma sequence
ABSTRACT: Colorectal adenocarcinoma (CRC) is a leading cause of cancer deaths globally. CRC tumorigenesis proceeds through a model of stepwise transformation of the colonic epithel...
Small molecule probes of MYC stability and function intumorigenesis
ABSTRACT MYC oncoproteins (including c-MYC, L-MYC and N-MYC) play critical roles in the initiation, progression and recurrence of many human malignancies. Extensive studies indicat...
Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma
ABSTRACT Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like surgery and chemotherapy, radi...
Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
PROJECT SUMMARY Multiple myeloma (MM) is a devastating clonal plasma cell (cPC) malignancy responsible for over 13,000 deaths in the US per year. It is always preceded by pre-malig...
Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices
Project Summary Lung and triple-negative breast cancers (TNBCs) are leading causes of cancer-related deaths in the U.S. This high mortality rate is largely due to their propensity...