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20,252 grants found
Showing 19,321 – 19,340 of 20,252 grants
SITE LICENSE TO AJCC CANCER STAGING MANUAL, 8TH EDITION
In order to continue the collection and reporting of cancer staging data by the SEER registries, the NCI/DCCPS SEER program requires access to the most current cancer staging data.
COG NCTN Network Group Operations Center
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically.T...
Dose finding designs for late-onset toxicities
Project Summary / Abstract: The current landscape of oncology drug development is posing a challenge to widely-accepted methods used in dose-finding clinical trials. One of the big...
TRPV1 nociceptors in oral carcinogenesis and pain
Project Summary Oral cancer pain is more severe than all other cancers. Patients with metastatic oral cancer experience the greatest pain. Oral cancers activate neurons and produce...
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
Summary More than 1.8 million people worldwide are diagnosed with non-small cell lung cancer (NSCLC) every year. Of these patients, 20% present with stage I or II disease. For thes...
Administrative Supplement for VICKtOrY Early Clinical Trials Consortium
ABSTRACT: This application is being submitted to request additional funds for three Affiliated Organizations (AOs) to an NCI Experimental Therapeutics-Clinical Trials Network (ETCT...
Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer
PROJECT SUMMARY Activating KRAS mutations, altered metabolism, and an immunosuppressive tumor microenvironment are all hallmarks of pancreatic ductal adenocarcinoma (PDAC). The rec...
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization
Clinical radiation therapy is a noninvasive means to mitigate cancer progression, which is prescribed for more than 50% of prostate cancer patients. Development of radiation techno...
COG NCTN Network Group Operations Center
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60-years ago, the prognosis of childhood cancer has improved dramatically.T...
COG SDMC - Administrative Core
PROJECT SUMMARY This is the Administrative Core to support the overall application for the Children's Oncology Group Statistics and Data Management Center.
Novel multipronged Immunovirotherapy Approach for GBM Treatment
Project Summary Glioblastoma (GBM) prognosis remains dismal with a median survival of 16-18 months despite the use of multimodality treatment. Immunotherapy attempts have been unsu...
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy
Cancers that depend on the spatial location of the disease affect all ethnicities and age groups, accounting for significant mortality and therapy-related side effects. In one inst...
PRECISE - a PErsonalized Risk Score for gastrIc CancEr
The National Cancer Institute has called for eliminating disparities in cancer morbidity and mortality through the use of Data Science. Gastric cancer remains one of the most unequ...
Characterizing genetic modifiers in tumor burden of Tuberous Sclerosis Complex
PROJECT SUMMARYTuberous Sclerosis Complex (TSC) is a genetic syndrome that predisposes patients to tumor formation and is often diagnosed during infancy. Brain lesions, including s...
A Multilevel intervention to address health disparities in lung cancer screening
Abstract Lung cancer is the leading cause of cancer-related mortality in the US, with more than 135,000 deaths expected in 2020. Based on the National Lung Screening Trial, which s...
Dissecting the Gut Microbiota for Immune Checkpoint Blockade (ICB) - Resisting Microbes and Exploring the Generalizability of Microbiota-ICB Studies
PROJECT SUMMARY Immune checkpoint blockade (ICB) has yielded durable tumor regression and stabilized disease in 10-30% of patients for a range of solid and hematological malignanci...
Lung epithelial lineage-specific factors in the control of immune system evasion genes in tumor cells
ABSTRACT Cancer cells that are capable of escaping host immune system defenses typically adopt more aggressive behaviors. Novel immunotherapies targeting these mechanisms are now s...
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
Project Summary Metastatic colorectal cancer (mCRC) is the second leading cause of cancer-related mortality in the United States, and annually accounts for nearly 500,000 deaths wo...
A transformative drug discovery platform for allosteric kinase inhibitors
Project Summary The University of Minnesota (UMN) and Photonic Pharma (PP) a Minnesota-based drug discovery start-up, have partnered to optimize, field-test, and deploy at industri...
Using mHealth to investigate intersectionality and health behaviors: Implications for conceptual models and cancer prevention interventions for marginalized populations
PROJECT SUMMARY/ABSTRACT Tobacco is the leading cause of preventable death and disease and is linked to approximately 20 cancers. The rate of decline of tobacco use has been lower...