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20,252 grants found
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Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity
PROJECT SUMMARY/ABSTRACT The candidate for this NCI Career Development Award is Max Jan, MD, PhD, who has completed clinical training in molecular genetic pathology and is a curren...
Defining the Mechanistic Determinants of Response to Selective Electron Transport Chain Inhibition in Cancer
Abstract: Cells utilize two major modes of energy metabolism: glycolysis and oxidative phosphorylation (OXPHOS).Efforts to target metabolism in cancer have mainly focused on glycol...
Chemical Proteomic Identification of Druggable Oncogenic Transcription Factors
Project Summary Advances in human genetics have identified +400 genes that when amplified or mutated promote tumorigenesis.While there has been huge success in developing drugs for...
Modeling Esophageal Squamous Cell Cancer Initiation
PROJECT SUMMARY/ABSTRACT Esophageal squamous cell carcinoma (ESCC) accounts for over 80% of all cases of esophageal cancer and has a poor prognosis because of a lack of symptoms at...
Prostate Cancer Radio-Pathomics for Differentiating Clinically Significant Disease
Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancer, affecting one in seven men. Even when treated with a radical prostatectomy, historically about 20% of...
A Multilevel intervention to address health disparities in lung cancer screening
Abstract Lung cancer is the leading cause of cancer-related mortality in the US, with more than 135,000 deaths expected in 2020.Based on the National Lung Screening Trial, which sh...
Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy
PROJECT SUMMARY/ABSTRACT The MMPs have long been recognized as potential targets for cancer therapy, but drugs developed to target these enzymes have been unsuccessful.A primary re...
Systemic delivery of an oncolytic adenovirus targeting TGFβ to enhance anti-PD-1 and anti-CTLA-4 therapy for triple negative breast cancer
PROJECT SUMMARY The development of novel therapies for the treatment of breast cancer is a major unmet need.In recent years, immune checkpoint inhibitors including anti-PD-1, anti-...
Developing novel polytherapies for Non-Clear Cell Renal Cell Carcinoma
PROJECT SUMMARY: Developing novel polytherapies for Non-Clear Cell Renal Carcinoma Non-clear cell renal cell carcinoma (NCCRCC) is the therapeutic outlier in kidney cancer because...
Covalent Protein Binders for Cancer Research and Therapy
Protein-protein interactions are involved in a broad range of cell function and signaling.Various protein binders have been developed to detect or modulate such interactions for re...
Precision targeting of T cell cytotoxicity with PET
The recent clinical success of inhibitors against immune checkpoint proteins (e.g. CTLA-4, PD-L1), which are thought to stimulate T cell responses against tumors, has revolutionize...
Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices
Project Summary Lung and triple-negative breast cancers (TNBCs) are leading causes of cancer-related deaths in the U.S. This high mortality rate is largely due to their propensity...
Leveraging an academic-industry partnership to develop a cancer-specific mobile meditation app
1 Project Summary/Abstract 2 Approximately 15.5 million US cancer patients/survivors experience a host of residual symptoms (e.g., 3 fatigue, anxiety, depression, pain, sleep distu...
Innovative Cell Therapy for Pediatric Acute Myeloid Leukemia
Abstract The parent R21 proposal 1R21CA245468-01A1 Innovative Cell Therapy for Pediatric Acute Myeloid Leukemia is designed to address the mechanism of pediatric acute myeloid leuk...
Metacognition and the Diagnostic Process in Pathology
Project Summary Metacognition, or one's ability to monitor their cognitive processes, guides problem-solving and improves the efficiency of such behavior (Davidson et al., 199...
Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axis
The overall 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) is less than 50%, and ~75% of human HNSCC cases have mutations in the tumor suppress...
Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma
Loss of function mutations in SMARCA4/BRG1, a tumor suppressor and core component of SWI/SNF chromatin remodeling complexes, occur frequently in lung adenocarcinoma (LAD) and harbo...
Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
PROJECT SUMMARY Multiple myeloma (MM) is a devastating clonal plasma cell (cPC) malignancy responsible for over 13,000 deaths in the US per year. It is always preceded by pre-malig...
Hyaluron as a regulator of chemotherapy-induced changes in neurogenesis
PROJECT SUMMARY In response to the COVID-19 pandemic, the Oregon Health and Science University (OHSU) made the decision to shut down laboratories and all but essential experiments...
Image-guided Interventional Combination Liver Cancer Immunotherapy
PROJECT SUMMARY For clinical application, a critical remaining hurdle for natural killer (NK) cell-based adoptive transfer immunotherapy (ATI) is the inadequate homing efficiency o...