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20,252 grants found
Showing 19,281 – 19,300 of 20,252 grants
Developing novel polytherapies for Non-Clear Cell Renal Cell Carcinoma
PROJECT SUMMARY: Developing novel polytherapies for Non-Clear Cell Renal Carcinoma Non-clear cell renal cell carcinoma (NCCRCC) is the therapeutic outlier in kidney cancer because...
Novel inhibitor for oncogenic RAS for lung cancer
Project Summary/Abstract: Aberrant activation of RAS signaling is a major driver of lung cancer resulting from gain-in-function mutations in RAS genes often caused by tobacco-deriv...
Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
Abstract: The Hippo pathway is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control,...
Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.
PROJECT SUMMARY Most children treated for cancer in the US will achieve long-term survival, and survivorship presents unique challenges for this growing population. Pediatric brain...
Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.
PROJECT SUMMARY Most children treated for cancer in the US will achieve long-term survival, and survivorship presents unique challenges for this growing population. Pediatric brain...
A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells
Abstract/Summary Chemotherapy and radiation can induce breast tumors to enter a prolonged state of growth arrest with characteristics of senescence. A senescent-like state is also...
ROS-induced SPIO Targeted Platform for Transarterial Liver Cancer Therapy
Title: SPIO-GOx conjugate for transarterial liver cancer therapy Abstract: Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and ranks third amongst canc...
Extracorporeal Filtration of Thermosensitive Liposomes
PROJECT SUMMARY/ABSTRACT This project will develop a device and perform proof-of-concept studies in a rodent tumor model. The device will remove the chemotherapy agent Doxorubicin...
Engineered adipokine receptor inhibitor for the treatment of triple negative breast cancer in obese patients
PROJECT SUMMARY An estimated 1 million cases of breast cancer (BC) are diagnosed annually worldwide. Of these, approximately 170,000 are triple-negative (ER-/PR-/HER2-) breast canc...
Development of Small Molecule Inhibitor of PELP1 for Treating Advanced Breast Cancer
PROJECT SUMMARY/ABSTRACT: Breast cancer (BC) is the most prevalent and second most lethal malignancy in females.Development of novel effective therapies for patients with therapy-r...
Impact of the Breast Cancer Immune Microenvironment on Racial Disparities and Survivorship
PROJECT SUMMARY Breast cancer (BC) is the most commonly diagnosed malignancy and second leading cause of cancer-related deaths among women in the US.Among all BC cases, black women...
Development of a combined ARFI/SWEI ultrasound elasticity imaging system for targeted prostate biopsy guidance
ABSTRACT Prostate cancer is the most common cancer among men in the United States, and early detection is crucial for effective treatment or management.Following an initial screeni...
Neoadjuvant Immunotherapy with Intratumoral CPG and PD-1 Blockade in Melanoma
PROJECT SUMMARY ABSTRACT High-risk resectable melanoma patients (MPs) with clinically detectable stage III with or without in-transit metastases have high-risk relapse1.Neoadjuvant...
Cancer cell state interactions with immune populations of the tumor microenvironment
SUMMARY Tumors are complex systems composed of genetically and transcriptionally heterogeneous cells, and this variation has been implicated as a cause of drug resistance and morta...
A novel strategy to overcome drug resistance in cancer
ABSTRACT The major obstacle to successful cancer therapy is the rapid development of drug resistance.While targeted therapies often extend overall survival in the subset of patient...
Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.
PROJECT SUMMARY Most children treated for cancer in the US will achieve long-term survival, and survivorship presents unique challenges for this growing population.Pediatric brain...
Cervical cancer in Botswana: Identifying demographic, clinical and geographical features
The World Health Organization estimates that there were 570,000 cervical cancer cases and 311,000 cervical cancer deaths in 2018. In Botswana, cervical cancer is the most commonly...
Rapid Breast Cancer Diagnosis in Low and Middle Income Countries
One of the biggest cancer challenges in low- and middle-income countries (LMICs) is the lack of access to accurate and affordable cellular and molecular diagnostics, which are esse...
The Role and Regulation of Monocarboxylate Transporters 1 and 4 in Epstein-Barr Virus-mediated B Lymphocyte Tumorigenesis
Epstein-Barr Virus (EBV) is a ubiquitous virus that establishes latency upon primary infection, but can hijack host metabolic pathways to promote tumorigenesis in immune-compromise...
Understanding PD-L1/L2 protein regulation, detection and signaling to predict melanoma therapeutic sensitivity
PROJECT SUMMARY/ABSTRACT Modulators and effectors of anti-PD-1 responsiveness in cancer include T cell infiltration, an immune- suppressive microenvironment, tumor mutational burde...