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20,252 grants found
Showing 19,261 – 19,280 of 20,252 grants
Elucidating the Role of C16orf72 in the Cellular Stress Response Network
PROJECT SUMMARY A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compound...
Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model
PROJECT SUMMARY/ABSTRACT Radiation plays a central role in the management of the most lethal central nervous system malignancy, glioblastoma (GBM), yet local control rates, and hen...
Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity
PROJECT SUMMARY/ABSTRACT The candidate for this NCI Career Development Award is Max Jan, MD, PhD, who has completed clinical training in molecular genetic pathology and is a curren...
Anti-tumor potential of temperature-sensitive p53 mutants
The p53 tumor suppressor is frequently inactivated by mutations in cancer. Most p53 point mutations are located in the DNA binding domain that prevent folding or disrupt the DNA bi...
A novel strategy to overcome drug resistance in cancer
ABSTRACT The major obstacle to successful cancer therapy is the rapid development of drug resistance. While targeted therapies often extend overall survival in the subset of patien...
TRPV1 nociceptors in oral carcinogenesis and pain
Project Summary Oral cancer pain is more severe than all other cancers. Patients with metastatic oral cancer experience the greatest pain. Oral cancers activate neurons and produce...
A novel therapeutic strategy to eradicate breast cancer through Hsp90 inhibition and reduced immune tolerance
Abstract: Immunotherapy is becoming a pillar of cancer treatment, and many responsive patients have experienced durable, or even curative, outcomes. For reasons that remain unclear...
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy
Cancers that depend on the spatial location of the disease affect all ethnicities and age groups, accounting for significant mortality and therapy-related side effects. In one inst...
Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy
PROJECT SUMMARY/ABSTRACT The MMPs have long been recognized as potential targets for cancer therapy, but drugs developed to target these enzymes have been unsuccessful. A primary r...
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study
Abstract Approximately 70,000 adolescents and young adults are diagnosed with cancer between the ages of 15-39 in the U.S. every year. Due to their age and life stage, the experien...
Reposition and Optimization of Deferiprone for Breast Cancer Therapy
Project Summary/Abstract: In 2020 there will be ~ 276,480 estimated new cases of invasive breast cancer (BCa) among women in the US, causing an estimated ~ 42,170 deaths. Two commo...
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
Summary More than 1.8 million people worldwide are diagnosed with non-small cell lung cancer (NSCLC) every year. Of these patients, 20% present with stage I or II disease. For thes...
The Unique Roles of Tumor-Specific Th9 Cells for Solid Tumor Eradication
Project Summary Our early studies have characterized IL-9-producing CD4+ T helper (Th9) cells as an antitumor T cell subset. Recently, we also revealed Th9 cells as a novel T cell...
Small molecule probes of MYC stability and function intumorigenesis
ABSTRACT MYC oncoproteins (including c-MYC, L-MYC and N-MYC) play critical roles in the initiation, progression and recurrence of many human malignancies. Extensive studies indicat...
Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling
ABSTRACT The tumor ecosystem plays a critical role in tumor development, progression and therapeutic response. Previous studies have utilized dissociative and single-cell omics tec...
Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer
The goal of this proposal is to define the role of each component of the ARTN/GFR3/TRPM8 signaling pathway in radiation-associated pain (RAP). A common consequence of radiotherapy...
Technology Facilitated Behavioral Intervention for Depression among Diverse Patients in Ambulatory Oncology
AbstractDepressionis one of the most common psychological comorbidities experienced throughout the cancercontinuum. Elevated depressive symptoms in oncology patients is a major con...
Image-guided Interventional Combination Liver Cancer Immunotherapy
PROJECT SUMMARY For clinical application, a critical remaining hurdle for natural killer (NK) cell-based adoptive transfer immunotherapy (ATI) is the inadequate homing efficiency o...
Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
PROJECT SUMMARY Chromatin-based DNA damage response (DDR) pathway is fundamental for protecting cells from genome instability, which is a hallmark of cancer. The DDR pathway is tig...
Precision targeting of T cell cytotoxicity with PET
The recent clinical success of inhibitors against immune checkpoint proteins (e.g. CTLA-4, PD-L1), which are thought to stimulate T cell responses against tumors, has revolutionize...