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20,252 grants found
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Systemic delivery of an oncolytic adenovirus targeting TGFβ to enhance anti-PD-1 and anti-CTLA-4 therapy for triple negative breast cancer
PROJECT SUMMARY The development of novel therapies for the treatment of breast cancer is a major unmet need. In recent years, immune checkpoint inhibitors including anti-PD-1, anti...
Lactate production by tumor associated macrophages promotes tumorigenesis
ABSTRACT Tumor-associated macrophages (TAMs) are the most prevalent immune cell in the tumor microenvironment. TAMs adopt an M2-like phenotype that supports angiogenesis, attenuate...
Novel multipronged Immunovirotherapy Approach for GBM Treatment
Project Summary Glioblastoma (GBM) prognosis remains dismal with a median survival of 16-18 months despite the use of multimodality treatment. Immunotherapy attempts have been unsu...
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancer
Triple negative breast cancers (TNBCs) do not express estrogen receptor-α (ERα), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2), and therefore, none...
Targeting Serine Auxotrophy in Luminal Breast Cancer
PROJECT SUMMARY/ABSTRACT A major challenge of targeting metabolism for cancer therapy is pathway redundancy, where multiple sources of critical nutrients can diminish the effects o...
Adhesion GPCR regulation of acute myeloid leukemia stem cells - Resubmission - 1
Despite advances in our understanding of the genetic origins of AML, treatment options have remained essentially unchanged for 30-years, and clinical outcomes remain poor. Leukemia...
Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices
Project Summary Lung and triple-negative breast cancers (TNBCs) are leading causes of cancer-related deaths in the U.S. This high mortality rate is largely due to their propensity...
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization
Clinical radiation therapy is a noninvasive means to mitigate cancer progression, which is prescribed for more than 50% of prostate cancer patients. Development of radiation techno...
TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity
ABSTRACT Spontaneous T cell pressure against an evolving tumor is a conserved mechanism of anti-tumor immune control. On the other hand, immune therapies directed to alleviate para...
Tumor Organoid-Mediated Drug Testing and Clonality Analysis in Peritoneal Surface Disease of Intestinal Origin
Project Summary The overarching goal of this project is to develop a tumor organoid-based drug screening platform that quantifies the differential drug responsiveness of tumor clon...
Neoadjuvant Immunotherapy with Intratumoral CPG and PD-1 Blockade in Melanoma
PROJECT SUMMARY ABSTRACT High-risk resectable melanoma patients (MPs) with clinically detectable stage III with or without in-transit metastases have high-risk relapse1. Neoadjuvan...
Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer
PROJECT SUMMARY Activating KRAS mutations, altered metabolism, and an immunosuppressive tumor microenvironment are all hallmarks of pancreatic ductal adenocarcinoma (PDAC). The rec...
The ASPIRES Study: Activating Cancer Survivors and their Primary Care Providers to Increase Colorectal Cancer Screening
Project Summary Childhood cancer survivors treated with abdominal or pelvic radiotherapy (RT) are almost four times more likely to develop colorectal cancer (CRC) compared to the g...
Mechanisms of immunotherapy response and resistance in pancreatic ductal adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy including immune checkpoint blockade. Meanwhile, immunotherapy targeting...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why...
Characterizing genetic modifiers in tumor burden of Tuberous Sclerosis Complex
PROJECT SUMMARYTuberous Sclerosis Complex (TSC) is a genetic syndrome that predisposes patients to tumor formation and is often diagnosed during infancy. Brain lesions, including s...
THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS
ABSTRACT Metastasis, the primary cause of breast cancer-related mortality, is a multistep process culminating with the formation of tumor foci within distant organs. However, only...
Characterizing the role of SRCAP in Epidermal Homeostasis and Squamous Cell Carcinoma
Project Summary/Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, disfiguring one million and killing 15,000 people per year in the United Sta...
Dissecting the Gut Microbiota for Immune Checkpoint Blockade (ICB) - Resisting Microbes and Exploring the Generalizability of Microbiota-ICB Studies
PROJECT SUMMARY Immune checkpoint blockade (ICB) has yielded durable tumor regression and stabilized disease in 10-30% of patients for a range of solid and hematological malignanci...
Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma
ABSTRACT Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like surgery and chemotherapy, radi...