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Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
PROJECT SUMMARY Multiple myeloma (MM) is a devastating clonal plasma cell (cPC) malignancy responsible for over 13,000 deaths in the US per year. It is always preceded by pre-malig...
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancer
Triple negative breast cancers (TNBCs) do not express estrogen receptor-α (ERα), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2), and therefore, none...
A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells
Parent Award Abstract/Summary (R01CA260819) Chemotherapy and radiation can induce breast tumors to enter a prolonged state of growth arrest with characteristics of senescence. A se...
Dissecting and Targeting RB1-Mutant Osteosarcoma
PROJECT SUMMARY/ABSTRACT Bone cancer is one of the most common primary malignancies in children and adolescents. Osteosarcoma comprises almost 60% of the common histological subtyp...
Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling
ABSTRACT The tumor ecosystem plays a critical role in tumor development, progression and therapeutic response. Previous studies have utilized dissociative and single-cell omics tec...
Adhesion GPCR regulation of acute myeloid leukemia stem cells - Resubmission - 1
Despite advances in our understanding of the genetic origins of AML, treatment options have remained essentially unchanged for 30-years, and clinical outcomes remain poor. Leukemia...
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study
Abstract Approximately 70,000 adolescents and young adults are diagnosed with cancer between the ages of 15-39 in the U.S. every year. Due to their age and life stage, the experien...
Role of Sirt2 in T Cell Metabolism
PROJECT SUMMARY Metabolism is a key driver of T cell functions, and the switch from oxidative-phosphorylation to aerobic glycolysis is a hallmark of T cell activation. Unfortunatel...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why...
Dissecting the Gut Microbiota for Immune Checkpoint Blockade (ICB) - Resisting Microbes and Exploring the Generalizability of Microbiota-ICB Studies
PROJECT SUMMARY Immune checkpoint blockade (ICB) has yielded durable tumor regression and stabilized disease in 10-30% of patients for a range of solid and hematological malignanci...
PRECISE - a PErsonalized Risk Score for gastrIc CancEr
The National Cancer Institute has called for eliminating disparities in cancer morbidity and mortality through the use of Data Science. Gastric cancer remains one of the most unequ...
Identifying the Role of Tumor Cell Intrinsic DNMT1 in Anti-Tumor Immunity in Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related death in the United States. The five-year survival rate of less than...
A transformative drug discovery platform for allosteric kinase inhibitors
Project Summary The University of Minnesota (UMN) and Photonic Pharma (PP) a Minnesota-based drug discovery start-up, have partnered to optimize, field-test, and deploy at industri...
Covalent Protein Binders for Cancer Research and Therapy
Protein-protein interactions are involved in a broad range of cell function and signaling. Various protein binders have been developed to detect or modulate such interactions for r...
Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma
Loss of function mutations in SMARCA4/BRG1, a tumor suppressor and core component of SWI/SNF chromatin remodeling complexes, occur frequently in lung adenocarcinoma (LAD) and harbo...
Dissecting and Targeting RB1-Mutant Osteosarcoma
PROJECT SUMMARY/ABSTRACT Bone cancer is one of the most common primary malignancies in children and adolescents. Osteosarcoma comprises almost 60% of the common histological subtyp...
Prostate Cancer Radio-Pathomics for Differentiating Clinically Significant Disease
Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancer, affecting one in seven men. Even when treated with a radical prostatectomy, historically about 20% of...
Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
PROJECT SUMMARY Multiple myeloma (MM) is a devastating clonal plasma cell (cPC) malignancy responsible for over 13,000 deaths in the US per year. It is always preceded by pre-malig...
Role of Sirt2 in T Cell Metabolism
PROJECT SUMMARY Metabolism is a key driver of T cell functions, and the switch from oxidative-phosphorylation to aerobic glycolysis is a hallmark of T cell activation. Unfortunatel...
Supernumerary Centrosomes and Cell Proliferation
PROJECT SUMMARY The centriole is a conserved organelle of metazoans that is found at the core of microtubule organizing centers, centrosomes, and at the base of cilia and flagellae...