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20,252 grants found
Showing 19,181 – 19,200 of 20,252 grants
BIOSPECIMEN PROCESSING CENTER (BPC) - EARLY ONSET MALIGNANCIES INITIATIVE
This Task Order provides support to the Early Onset Malignancies Initiative (EOMI).The EOMI is a collaborative initiative between CCG and the Division of Cancer Prevention’s NCI Co...
Laboratory to Perform Assays of Coagulopathy Biomarkers for the National Cancer Institute’s COVID-19 in Cancer Patients Study (NCCAPS)
Lab will conduct coagulopathy assays for NCI to analyze as part of a correlative science objective in NCI COVID-19 in Cancer Patients Study (NCCAPS): A Longitudinal Natural History...
Elucidating the role of somatic 3’UTR mutations in prostate cancer pathogenesis
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer mortality in US men due to our poor understanding and treatment of metastatic, castration-resistant prosta...
Multilevel investigation of uncertain and reclassified genomic variants in clinical oncology
PROJECT SUMMARY/ABSTRACT The overarching goal of this award is to prepare the applicant for an independent, sustained program of research that incorporates psychosocial, behavioral...
Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
PROJECT SUMMARY Chromatin-based DNA damage response (DDR) pathway is fundamental for protecting cells from genome instability, which is a hallmark of cancer. The DDR pathway is tig...
PRECISE - a PErsonalized Risk Score for gastrIc CancEr
The National Cancer Institute has called for eliminating disparities in cancer morbidity and mortality through the use of Data Science. Gastric cancer remains one of the most unequ...
Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma
Loss of function mutations in SMARCA4/BRG1, a tumor suppressor and core component of SWI/SNF chromatin remodeling complexes, occur frequently in lung adenocarcinoma (LAD) and harbo...
Cancer cell state interactions with immune populations of the tumor microenvironment
SUMMARY Tumors are complex systems composed of genetically and transcriptionally heterogeneous cells, and this variation has been implicated as a cause of drug resistance and morta...
TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity
ABSTRACT Spontaneous T cell pressure against an evolving tumor is a conserved mechanism of anti-tumor immune control. On the other hand, immune therapies directed to alleviate para...
Developing novel polytherapies for Non-Clear Cell Renal Cell Carcinoma
PROJECT SUMMARY: Developing novel polytherapies for Non-Clear Cell Renal Carcinoma Non-clear cell renal cell carcinoma (NCCRCC) is the therapeutic outlier in kidney cancer because...
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
Summary More than 1.8 million people worldwide are diagnosed with non-small cell lung cancer (NSCLC) every year. Of these patients, 20% present with stage I or II disease. For thes...
Novel multipronged Immunovirotherapy Approach for GBM Treatment
Project Summary Glioblastoma (GBM) prognosis remains dismal with a median survival of 16-18 months despite the use of multimodality treatment. Immunotherapy attempts have been unsu...
Characterizing the role of SRCAP in Epidermal Homeostasis and Squamous Cell Carcinoma
Project Summary/Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, disfiguring one million and killing 15,000 people per year in the United Sta...
Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy
PROJECT SUMMARY/ABSTRACT The MMPs have long been recognized as potential targets for cancer therapy, but drugs developed to target these enzymes have been unsuccessful. A primary r...
Precision targeting of T cell cytotoxicity with PET
The recent clinical success of inhibitors against immune checkpoint proteins (e.g. CTLA-4, PD-L1), which are thought to stimulate T cell responses against tumors, has revolutionize...
Systemic delivery of an oncolytic adenovirus targeting TGFβ to enhance anti-PD-1 and anti-CTLA-4 therapy for triple negative breast cancer
PROJECT SUMMARY The development of novel therapies for the treatment of breast cancer is a major unmet need. In recent years, immune checkpoint inhibitors including anti-PD-1, anti...
Prostate Cancer Radio-Pathomics for Differentiating Clinically Significant Disease
Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancer, affecting one in seven men. Even when treated with a radical prostatectomy, historically about 20% of...
Covalent Protein Binders for Cancer Research and Therapy
Protein-protein interactions are involved in a broad range of cell function and signaling. Various protein binders have been developed to detect or modulate such interactions for r...
Elucidating the role of somatic 3’UTR mutations in prostate cancer pathogenesis
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer mortality in US men due to our poor understanding and treatment of metastatic, castration-resistant prosta...
A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells
Abstract/Summary Chemotherapy and radiation can induce breast tumors to enter a prolonged state of growth arrest with characteristics of senescence. A senescent-like state is also...