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20,252 grants found
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Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
PROJECT SUMMARY/ABSTRACT This mentored career development award proposal will facilitate my career goal to become an independent translational researcher using advances in experime...
Large-scale artificial intelligence using radiomics, deep learning, and physics-based generative modeling to improve clinical outcomes in nuclear medicine
Project Summary/Abstract Cancer is the second leading cause of death in the United States where delays in diagnosis and treatment lead to increased mortality and advanced-stage dis...
A new generation of misleading tobacco marketing: Assessing the evolution of misleading combustible tobacco marketing features and detrimental implications for vulnerable youth and young adults
Project Summary/Abstract The purpose of this research is to assess the use and effects of a new generation of misleading descriptors and imagery in combustible tobacco marketing. W...
Function of the METTL3-NUP93 complex-mediated nuclear export of m6A-modified mRNAs in castration-resistant prostate cancer.
PROJECT SUMMARY/ABSTRACT Misregulation of nucleoporins (NUPs), the essential constituents of nuclear pore complexes (NPCs), and dysfunction of N6-methyladenosine (m6A) signaling ha...
Fibrotic remodeling of lymph nodes disrupts T cell function in fibrosis and cancer
Project Summary/Abstract Fibrosis is a hallmark of cancer that promotes proliferation, metastasis, and immune evasion by altering the tumor stroma which accounts for up to 90% of t...
Countering E-cigarette Marketing in the Retail Environment among Adolescents and Young Adults
PROJECT SUMMARY/ ABSTRACT Despite significant efforts to limit youth from accessing and using electronic cigarettes (e-cigarettes), many adolescents and young adults are directly p...
Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance
ABSTRACT Support is requested for a Keystone Symposia conference entitled Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance, organized by Drs. James...
Commercial Readiness for Direct-to-Digital Pathology
Project Summary Applikate Technologies has developed Clearing Histology with Multiphoton Microscopy (CHiMP), a novel tissue processing and imaging platform that provides direct-to-...
Dissecting reciprocal interactions between cancer cells and endothelial cells in SCLC liver metastasis.
PROJECT SUMMARY / ABSTRACT Small cell lung cancer (SCLC) is a recalcitrant cancer that causes 250,000 deaths worldwide each year. Patients with SCLC initially respond to cytotoxic...
Northwestern University Lead Academic Participating Site - Revision -5S2
Summary/Abstract: The Robert H. Lurie Comprehensive Cancer Center of Northwestern University (LCC) has a long history of NCTN participation with ECOG membership since 1973. Current...
NURTURE: Northwestern University Recruitment to Transform UnderRepresentation and achieve Equity
Contact PD/PI: SIMON, MELISSA A. Project Summary/Abstract
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
Project Summary While several innovative and creative immuno-oncology (IO) strategies have shown promising results, a significant expansion of their clinical use will require colla...
The molecular basis of 7SK RNA methylation in non-small cell lung cancer
PROJECT SUMMARY Lung cancer is a leading cause of cancer death in the United States, with non-small cell lung cancer (NSCLC) being the major subtype accounting for approximately 85...
Is ERBB4 a Driver of BRAF WT Melanomas?
Combining immune checkpoint inhibitors with BRAF and MEK inhibitors has enabled significant improvements in treating metastatic skin cutaneous melanomas that possess activating mut...
Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.
SUMMARY, Project 2 Radiation therapy (RT) is commonly used for locally recurrent head and neck squamous cell carcinoma (HNSCCs), yet no standard concomitant systemic therapy exists...
Administrative Core
ADMINISTRATIVE CORE―ABSTRACT The Administrative Core (AdminCore) will drive the mission of the NURTURE: Northwestern University Recruitment to Transform Under-Representation and ac...
CCSG Supplement: Assessing Facilitators and Barriers to Implementation of the National Survivorship Care Standards in Rural Health Systems
PROJECT SUMMARY/ABSTRACT This application s being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-24-041. There are more than 18 million cancer...
Anti-Complement Immunotherapy for Pancreatic Cancer
PROJECT SUMMARY / ABSTRACT Pancreatic Ductal Adenocarcinoma (PDAC) is an almost uniformly lethal disease, with an overall survival under 10%. Despite therapeutic advances in all ar...
Designing Rational Combinations to Improve CAR T Cell Therapy for Prostate Cancer
PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy is a type of immunotherapy that has shown clinical success in treating hematological malignancies but faces multiple...
Commercial Readiness for Direct-to-Digital Pathology
Project Summary Applikate Technologies has developed Clearing Histology with Multiphoton Microscopy (CHiMP), a novel tissue processing and imaging platform that provides direct-to-...