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20,252 grants found
Showing 19,161 – 19,180 of 20,252 grants
Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma
ABSTRACT Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like surgery and chemotherapy, radi...
Multi-atlas and whole body radiomics approaches for image-guided treatment of gynecologic cancers
ABSTRACT Gynecologic cancers are among the leading causes of cancer death in women worldwide. These patients typically are socioeconomically disadvantaged, with poor access to scre...
Cancer cell state interactions with immune populations of the tumor microenvironment
SUMMARY Tumors are complex systems composed of genetically and transcriptionally heterogeneous cells, and this variation has been implicated as a cause of drug resistance and morta...
Development of Small Molecule Inhibitor of PELP1 for Treating Advanced Breast Cancer
PROJECT SUMMARY/ABSTRACT: Breast cancer (BC) is the most prevalent and second most lethal malignancy in females. Development of novel effective therapies for patients with therapy-...
Defining the Mechanistic Determinants of Response to Selective Electron Transport Chain Inhibition in Cancer
Abstract: Cells utilize two major modes of energy metabolism: glycolysis and oxidative phosphorylation (OXPHOS). Efforts to target metabolism in cancer have mainly focused on glyco...
Frequency and consequences of chromosome missegregation in breast cancer
PROJECT SUMMARY Research. Chromosomal instability (CIN) – observed as the first cancer hallmark over 100-years ago – is characterized by the persistent loss and gain of whole chrom...
Impact of the Breast Cancer Immune Microenvironment on Racial Disparities and Survivorship
PROJECT SUMMARY Breast cancer (BC) is the most commonly diagnosed malignancy and second leading cause of cancer-related deaths among women in the US. Among all BC cases, black wome...
Elucidating the role of somatic 3’UTR mutations in prostate cancer pathogenesis
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer mortality in US men due to our poor understanding and treatment of metastatic, castration-resistant prosta...
Characterizing the role of SRCAP in Epidermal Homeostasis and Squamous Cell Carcinoma
Project Summary/Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, disfiguring one million and killing 15,000 people per year in the United Sta...
The Role and Regulation of Monocarboxylate Transporters 1 and 4 in Epstein-Barr Virus-mediated B Lymphocyte Tumorigenesis
Epstein-Barr Virus (EBV) is a ubiquitous virus that establishes latency upon primary infection, but can hijack host metabolic pathways to promote tumorigenesis in immune-compromise...
Engineering Hybrid SynNotch CAR Receptors to Enhance Cell Therapies for Cancer
Chimeric Antigen T Cell (CAR-T) therapies, which redirect a patient’s own T cells towards their cancer, are very promising therapies for difficult to treat and refractory cancers....
Identifying the Role of Tumor Cell Intrinsic DNMT1 in Anti-Tumor Immunity in Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related death in the United States. The five-year survival rate of less than...
Investigating a Wnt-telomere feedback loop in the colorectal adenoma-carcinoma sequence
ABSTRACT: Colorectal adenocarcinoma (CRC) is a leading cause of cancer deaths globally. CRC tumorigenesis proceeds through a model of stepwise transformation of the colonic epithel...
Image-guided Interventional Combination Liver Cancer Immunotherapy
PROJECT SUMMARY For clinical application, a critical remaining hurdle for natural killer (NK) cell-based adoptive transfer immunotherapy (ATI) is the inadequate homing efficiency o...
The Mitochondrial Calcium Uniporter in Pancreatic Cancer Development, Metastasis, and Treatment
Summary: Pancreatic adenocarcinoma (PDAC) is a particularly lethal form of cancer which kills over 40,000 Americans every year. PDAC is most often diagnosed when disease is advance...
Elucidating the Role of C16orf72 in the Cellular Stress Response Network
PROJECT SUMMARY A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compound...
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy
Cancers that depend on the spatial location of the disease affect all ethnicities and age groups, accounting for significant mortality and therapy-related side effects. In one inst...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why...
The Unique Roles of Tumor-Specific Th9 Cells for Solid Tumor Eradication
Project Summary Our early studies have characterized IL-9-producing CD4+ T helper (Th9) cells as an antitumor T cell subset. Recently, we also revealed Th9 cells as a novel T cell...
REGISTRATION, STORAGE AND DISTRIBUTION OF CHEMICALS AND DRUGS FOR PRE-CLINICAL DISCOVERY EVALUATION AND DEVELOPMENT
The Drug Synthesis and Chemistry Branch (DSCB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the National Cancer Insti...