Browse All Grants
20,252 grants found
Showing 19,101 – 19,120 of 20,252 grants
Lactate production by tumor associated macrophages promotes tumorigenesis
ABSTRACT Tumor-associated macrophages (TAMs) are the most prevalent immune cell in the tumor microenvironment.TAMs adopt an M2-like phenotype that supports angiogenesis, attenuates...
Pathogenetic roles of USO1 in leukemogenesis
PROJECT SUMMARY B-acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children.The protein USO1 is specifically overexpressed in B-acute lymphoblastic leukemia (B...
PRECISE - a PErsonalized Risk Score for gastrIc CancEr
The National Cancer Institute has called for eliminating disparities in cancer morbidity and mortality through the use of Data Science.Gastric cancer remains one of the most unequa...
Using mHealth to investigate intersectionality and health behaviors: Implications for conceptual models and cancer prevention interventions for marginalized populations
PROJECT SUMMARY/ABSTRACT Tobacco is the leading cause of preventable death and disease and is linked to approximately 20 cancers. The rate of decline of tobacco use has been lower...
Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer
PROJECT SUMMARY Activating KRAS mutations, altered metabolism, and an immunosuppressive tumor microenvironment are all hallmarks of pancreatic ductal adenocarcinoma (PDAC).The rece...
Engineering Hybrid SynNotch CAR Receptors to Enhance Cell Therapies for Cancer
Chimeric Antigen T Cell (CAR-T) therapies, which redirect a patient?s own T cells towards their cancer, are very promising therapies for difficult to treat and refractory cancers.W...
The Mitochondrial Calcium Uniporter in Pancreatic Cancer Development, Metastasis, and Treatment
Summary: Pancreatic adenocarcinoma (PDAC) is a particularly lethal form of cancer which kills over 40,000 Americans every year. PDAC is most often diagnosed when disease is advance...
Identifying the Role of Tumor Cell Intrinsic DNMT1 in Anti-Tumor Immunity in Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related death in the United States.The five-year survival rate of less than n...
Elucidating the role of somatic 3’UTR mutations in prostate cancer pathogenesis
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer mortality in US men due to our poor understanding and treatment of metastatic, castration-resistant prosta...
Investigating a Wnt-telomere feedback loop in the colorectal adenoma-carcinoma sequence
ABSTRACT: Colorectal adenocarcinoma (CRC) is a leading cause of cancer deaths globally.CRC tumorigenesis proceeds through a model of stepwise transformation of the colonic epitheli...
A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells
Abstract/Summary Chemotherapy and radiation can induce breast tumors to enter a prolonged state of growth arrest with characteristics of senescence.A senescent-like state is also c...
Characterizing the role of SRCAP in Epidermal Homeostasis and Squamous Cell Carcinoma
Project Summary/Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy, disfiguring one million and killing 15,000 people per year in the United Sta...
Cancer Stem Cells: Advances in Biology and Clinical Translation
ABSTRACT Support is requested for a Keystone Symposia conference entitled Cancer Stem Cells: Advances in Biology and Clinical Translation, organized by Drs. Irene Oi Lin Ng, Xin We...
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization
Clinical radiation therapy is a noninvasive means to mitigate cancer progression, which is prescribed for more than 50% of prostate cancer patients.Development of radiation technol...
Elucidating the Role of C16orf72 in the Cellular Stress Response Network
PROJECT SUMMARY A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compound...
Frequency and consequences of chromosome missegregation in breast cancer
PROJECT SUMMARY Research.Chromosomal instability (CIN) ? observed as the first cancer hallmark over 100-years ago ? is characterized by the persistent loss and gain of whole chromo...
Small molecule probes of MYC stability and function intumorigenesis
ABSTRACT MYC oncoproteins (including c-MYC, L-MYC and N-MYC) play critical roles in the initiation, progression and recurrence of many human malignancies. Extensive studies indicat...
Dissecting the Gut Microbiota for Immune Checkpoint Blockade (ICB) - Resisting Microbes and Exploring the Generalizability of Microbiota-ICB Studies
PROJECT SUMMARY Immune checkpoint blockade (ICB) has yielded durable tumor regression and stabilized disease in 10-30% of patients for a range of solid and hematological malignanci...
XPO1 inhibitors Selinexor and Eltanexor in Combination with Venetoclax and Decitabine (ASTX727) in AML
a) Project Summary Our studies have shown that the nuclear export inhibitors selinexor and eltanexor are highly active against AML cells and leukemia initiating cells (LICs) in pat...
Integration of single cell sequencing as a biomarker of PARP inhibitor response for IDH1 and IDH2 mutated AML and MDS
Project Summary/Abstract Meningioma is the most common intracranial tumor and affects approximately 150,000 individuals in the USA.Approximately 10-20% of them will eventually deve...