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20,252 grants found
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Supernumerary Centrosomes and Cell Proliferation
PROJECT SUMMARY The centriole is a conserved organelle of metazoans that is found at the core of microtubule organizing centers, centrosomes, and at the base of cilia and flagellae...
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
Project Summary Metastatic colorectal cancer (mCRC) is the second leading cause of cancer-related mortality in the United States, and annually accounts for nearly 500,000 deaths wo...
Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma
Loss of function mutations in SMARCA4/BRG1, a tumor suppressor and core component of SWI/SNF chromatin remodeling complexes, occur frequently in lung adenocarcinoma (LAD) and harbo...
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer Therapy
Cancers that depend on the spatial location of the disease affect all ethnicities and age groups, accounting for significant mortality and therapy-related side effects.In one insta...
TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity
ABSTRACT Spontaneous T cell pressure against an evolving tumor is a conserved mechanism of anti-tumor immune control.On the other hand, immune therapies directed to alleviate paral...
Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis
Abstract: The Hippo pathway is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control,...
TURNing RanBP9 on NSCLC
Project Summary Remarkable advancements have been recently achieved in the treatment of Non-Small Cell Lung Cancer (NSCLC).Targeted- and immune-therapy have produced spectacular pa...
Immune Regulation of Disseminated Cancer Cell Dormancy
SUMMARY: Most cancer patients do not die from primary tumors but from the metastatic disease.Before formation of lethal metastases, disseminated cancer cells (DCCs) may stay dorman...
Novel 7SK non-coding RNA fusions in soft tissue sarcomas to tumorigenesis
PROJECT SUMMARY Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin that are often characterized by diagnostic fusion oncoproteins corresponding with tumor subtype.We...
Understanding the impact of the Affordable Care Act on cancer treatment and outcomes for adolescents and young adults (AYA)
Adolescents and young adults (AYAs; diagnosed with cancer at ages 15-39-years) have lagged in improvements in cancer survival seen among younger and older populations.A major barri...
Lung epithelial lineage-specific factors in the control of immune system evasion genes in tumor cells
ABSTRACT Cancer cells that are capable of escaping host immune system defenses typically adopt more aggressive behaviors.Novel immunotherapies targeting these mechanisms are now su...
Dose finding designs for late-onset toxicities
Project Summary / Abstract: The current landscape of oncology drug development is posing a challenge to widely-accepted methods used in dose-finding clinical trials.One of the bigg...
Targeting Serine Auxotrophy in Luminal Breast Cancer
PROJECT SUMMARY/ABSTRACT A major challenge of targeting metabolism for cancer therapy is pathway redundancy, where multiple sources of critical nutrients can diminish the effects o...
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
Summary More than 1.8 million people worldwide are diagnosed with non-small cell lung cancer (NSCLC) every year. Of these patients, 20% present with stage I or II disease.For these...
Role of LSD1 in Triple Negative Breast Cancer Development and Therapeutic Response
PROJECT SUMMARY/ABSTRACT Breast cancer (BC) is the most common cancer and the second leading cause of cancer death in American women.About 10-20% of breast cancers are triple-negat...
Anti-tumor potential of temperature-sensitive p53 mutants
The p53 tumor suppressor is frequently inactivated by mutations in cancer. Most p53 point mutations are located in the DNA binding domain that prevent folding or disrupt the DNA bi...
Reposition and Optimization of Deferiprone for Breast Cancer Therapy
Project Summary/Abstract: In 2020 there will be ~ 276,480 estimated new cases of invasive breast cancer (BCa) among women in the US, causing an estimated ~ 42,170 deaths.Two common...
Mechanisms of immunotherapy response and resistance in pancreatic ductal adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy including immune checkpoint blockade.Meanwhile, immunotherapy targeting...
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancer
Triple negative breast cancers (TNBCs) do not express estrogen receptor-? (ER?), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2), and therefore, none...
Adhesion GPCR regulation of acute myeloid leukemia stem cells - Resubmission - 1
Despite advances in our understanding of the genetic origins of AML, treatment options have remained essentially unchanged for 30-years, and clinical outcomes remain poor.Leukemia...