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20,252 grants found
Showing 19,061 – 19,080 of 20,252 grants
Mechanism of chemotherapy potentiation of muscle wasting in cancer cachexia
Summary Chemotherapy is a mainstream treatment for most cancers, despite recent progress in the development of new therapies for cancer. A well-documented long lasting toxicity of...
Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches
PROJECT SUMMARY/ABSTRACT Although genome-wide association studies (GWAS) have been extremely successful in identifying numerous germline variants associated to risk for prostate ca...
Mechanism of chemotherapy potentiation of muscle wasting in cancer cachexia
Summary Chemotherapy is a mainstream treatment for most cancers, despite recent progress in the development of new therapies for cancer.A well-documented long lasting toxicity of s...
Exosomal CD44 in the metastasis of triple negative breast cancer
Abstract The objective of this proposal is to determine the functions of breast cancer cell-secreted exosomes in regulating tumor motility, stemness, and immune evasion.Our prelimi...
Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches
PROJECT SUMMARY/ABSTRACT Although genome-wide association studies (GWAS) have been extremely successful in identifying numerous germline variants associated to risk for prostate ca...
Evaluating the role of EZH2-interacting protein (EZHIP) in pediatric posterior fossa ependymoma metabolism
ABSTRACT Pediatric ependymomas are the third-most common malignancy of the central nervous system.While they arise in different places of the neuraxis, these tumors are most common...
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study
Abstract Approximately 70,000 adolescents and young adults are diagnosed with cancer between the ages of 15-39 in the U.S. every year.Due to their age and life stage, the experienc...
Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model
PROJECT SUMMARY/ABSTRACT Radiation plays a central role in the management of the most lethal central nervous system malignancy, glioblastoma (GBM), yet local control rates, and hen...
Mechanisms of translational output control in pancreatic cancer
PROJECT SUMMARY My long-term career goal is to lead a productive academic research group, promoting science by conducting impactful cancer biology research and mentoring the next g...
Multi-atlas and whole body radiomics approaches for image-guided treatment of gynecologic cancers
ABSTRACT Gynecologic cancers are among the leading causes of cancer death in women worldwide. These patients typically are socioeconomically disadvantaged, with poor access to scre...
Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
PROJECT SUMMARY Chromatin-based DNA damage response (DDR) pathway is fundamental for protecting cells from genome instability, which is a hallmark of cancer. The DDR pathway is tig...
Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling
ABSTRACT The tumor ecosystem plays a critical role in tumor development, progression and therapeutic response.Previous studies have utilized dissociative and single-cell omics tech...
Image-based models of tumor-immune dynamics in glioblastoma
ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research.However, our inability to explain why s...
Evaluation of TRPM8-expressing neurons as novel regulators of acute radiotherapy-associated pain in patients with head and neck cancer
The goal of this proposal is to define the role of each component of the ARTN/GFR?3/TRPM8 signaling pathway in radiation-associated pain (RAP). A common consequence of radiotherapy...
Targeting Nucleotide Metabolism to Overcome Therapy Resistance in Glioblastoma
ABSTRACT Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years.Like surgery and chemotherapy, radia...
Platelet Serine/Threonine Phosphatases in Cancer Pathophysiology
The five year survival rate for lung cancer is ~20% despite improved screening methods and advances in treatment. Tumor metastasis is one of the major causes of death in cancer pat...
A novel therapeutic strategy to eradicate breast cancer through Hsp90 inhibition and reduced immune tolerance
Abstract: Immunotherapy is becoming a pillar of cancer treatment, and many responsive patients have experienced durable, or even curative, outcomes.For reasons that remain unclear,...
Tumor Organoid-Mediated Drug Testing and Clonality Analysis in Peritoneal Surface Disease of Intestinal Origin
Project Summary The overarching goal of this project is to develop a tumor organoid-based drug screening platform that quantifies the differential drug responsiveness of tumor clon...
Technology Facilitated Behavioral Intervention for Depression among Diverse Patients in Ambulatory Oncology
Abstract Depressionis one of the most common psychological comorbidities experienced throughout the cancercontinuum.Elevated depressive symptoms in oncology patients is a major con...
Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastoma
PROJECT SUMMARY: Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median survival of up to 20 months. Males have a 1.6-fold higher incidence of GBM compa...