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20,252 grants found
Showing 19,041 – 19,060 of 20,252 grants
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML Abstract Acute myeloid leukemia (AML) is a malignant hematopoietic disease and the most...
Multimodal iterative sequencing of cancer genomes and single tumor cells
ABSTRACT Genome sequencing technology has been transformative in the analysis of cancer.From genomic, transcriptomic, and epigenetic data, researchers are making new d...
Dihydroceramide desaturase (DES1) as a mediator of receptor tyrosine kinase-driven metastasis in breast cancer
ABSTRACT Despite improvements in treatment, clinical outcomes for late stage breast cancer (BC) remain poor and there is a critical need for new therapies for metastatic disease.Hy...
Development of A HTLV-1 Vaccine
PROJECT SUMMARY For this proposal we intend to develop a novel vaccine to prevent and possibly treat Human T cell leukemia virus type-1 (HTLV-1) associated diseases.HTLV-1 is a hum...
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML Abstract Acute myeloid leukemia (AML) is a malignant hematopoietic disease and the most...
Large scale clinical and economic impact analysis of potentially malignant incidental findings in radiology reports
Abstract Unexpected findings, or incidentalomas, are increasing dramatically with the growth in the use of imaging technology within healthcare organizations. Incidentalomas may in...
Large scale clinical and economic impact analysis of potentially malignant incidental findings in radiology reports
Abstract Unexpected findings, or incidentalomas, are increasing dramatically with the growth in the use of imaging technology within healthcare organizations. Incidentalomas may in...
Dihydroceramide desaturase (DES1) as a mediator of receptor tyrosine kinase-driven metastasis in breast cancer
ABSTRACT Despite improvements in treatment, clinical outcomes for late stage breast cancer (BC) remain poor and there is a critical need for new therapies for metastatic disease. H...
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AML Abstract Acute myeloid leukemia (AML) is a malignant hematopoietic disease and the most...
Multimodal iterative sequencing of cancer genomes and single tumor cells
ABSTRACT Genome sequencing technology has been transformative in the analysis of cancer. From genomic, transcriptomic, and epigenetic data, researchers are making new...
Development of A HTLV-1 Vaccine
PROJECT SUMMARY For this proposal we intend to develop a novel vaccine to prevent and possibly treat Human T cell leukemia virus type-1 (HTLV-1) associated diseases. HTLV-1 is a hu...
A community-based trial of a voluntary smoke-free home intervention in permanent supportive housing for formerly homeless adults
PROJECT SUMMARY The focus of this proposal is on expanding access to voluntary smoke-free homes to formerly homeless residents residing in permanent supportive housing, and examini...
SEER CORE INFRASTRUCTURE SUPPORT
The purpose of the National Cancer Institute (NCI) Surveillance Epidemiology and End Results (SEER) Program is to assemble and report annual estimates of cancer statistics that per...
SEER CORE INFRASTRUCTURE SUPPORT
The purpose of the National Cancer Institute (NCI) Surveillance Epidemiology and End Results (SEER) Program is to assemble and report annual estimates of cancer statistics that per...
Mechanism of chemotherapy potentiation of muscle wasting in cancer cachexia
Summary Chemotherapy is a mainstream treatment for most cancers, despite recent progress in the development of new therapies for cancer. A well-documented long lasting toxicity of...
Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches
PROJECT SUMMARY/ABSTRACT Although genome-wide association studies (GWAS) have been extremely successful in identifying numerous germline variants associated to risk for prostate ca...
Exosomal CD44 in the metastasis of triple negative breast cancer
Abstract The objective of this proposal is to determine the functions of breast cancer cell-secreted exosomes in regulating tumor motility, stemness, and immune evasion. Our prelim...
Evaluating the role of EZH2-interacting protein (EZHIP) in pediatric posterior fossa ependymoma metabolism
ABSTRACT Pediatric ependymomas are the third-most common malignancy of the central nervous system. While they arise in different places of the neuraxis, these tumors are most commo...
Mechanism of chemotherapy potentiation of muscle wasting in cancer cachexia
Summary Chemotherapy is a mainstream treatment for most cancers, despite recent progress in the development of new therapies for cancer. A well-documented long lasting toxicity of...
Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches
PROJECT SUMMARY/ABSTRACT Although genome-wide association studies (GWAS) have been extremely successful in identifying numerous germline variants associated to risk for prostate ca...