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20,252 grants found
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The role of flavor in the substitutability of e-cigarettes for combustible cigarettes among persistent smokers
PROJECT SUMMARY The average smoker will attempt to quit smoking at least 30 times before abstaining for 12 months or longer. These attempts typically occur over decades of smoking,...
Defining the tumor suppressive mechanism of the kinase STK25
Abstract The maintenance of cellular and tissue homeostasis relies on the tight regulation of cell growth and proliferation. This regulation is predominantly controlled by two evol...
Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase
Lung cancer is the primary cause of cancer death in western countries, including the United States. Kentucky leads the nation both in lung cancer incidence and mortality. Lung canc...
FBXL16 as a novel factor in promoting endocrine therapy resistance and metastasis of ER+ breast cancer
Project summary Endocrine therapy (ET) resistance and metastasis are major obstacles for curing patients with advanced ERα+ breast cancer (ER+ BC). Upregulated oncogenic ERα activi...
Improving Accuracy of Next-Generation Microscopy for Early Stage Metastatic Melanoma Detection
Our focus is on translation of a novel microscopy approach, femtosecond pump-probe microscopy, which our preliminary data shows can determine which (nominally) early-stage primary...
Development of adverse event (AE) derived biomarkers for predicting clinical outcomes in lung cancer
PROJECT SUMMARY/ABSTRACT Adverse event (AE) is a critical component of clinical trial for safety data to protect patients from unnecessary risk and to develop safety profile of the...
Exosome-mediated therapy for liver cancer
Hepatocellular carcinoma (HCC) is the most common primary liver cancer that represents the second most common cause of cancer-related death worldwide. In addition, the liver the mo...
SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT)
PROJECT SUMMARY/ABSTRACT A decrease in muscle mass and function, known as sarcopenia, is highly prevalent in cancer patients and often leads to decreased endurance, increased fatig...
The role of pyruvate kinase as a therapeutic target in T-ALL
ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that occurs primarily in children but can also occur in adults. Despite recent advances...
A novel uterine leiomyosarcoma mouse model for therapeutic development
Title: A novel uterine leiomyosarcoma mouse model for therapeutic development PROJECT SUMMARY: Uterine leiomyosarcoma is an extremely rare but clinically aggressive uterine cancer...
Dissemination of a breast reconstruction decision tool through social media and online communities
PROJECT SUMMARY Breast reconstruction after mastectomy is critical to comprehensive breast cancer treatment because it can restore quality of life and body image, which are often i...
Merkel cell polyomavirus HLA class I epitopes for generating therapeutic T cell-based cancer immunotherapy
Summary Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with an incidence of 3,000 USA cases/year. MCC carries a 2-year mortality of 40% with clear unmet medical nee...
Cytokine-mediated regulation of immunity and microenvironment in colorectal cancer metastasis
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a second cause of cancer-related mortality because of metastatic disease represented by liver and peritoneal metastasis. This di...
Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides
Mycosis Fungoides (MF) is a clonal disorder of skin-resident memory T cells and is the most common form of cutaneous T-cell lymphoma (CTCL). In the early stages of MF, T cells resi...
Translation of Noninvasive Metabolic Biomarkers to Targeted Therapy for Cancer
TRANSLATION OF NONINVASIVE METABOLIC BIOMARKERS TO TARGETED THERAPY FOR CANCER PROJECT SUMMARY/ABSTRACT The genetic mutations that make a living cell become cancer produce faulty s...
Cardiopulmonary function and cerebral blood flow in Hodgkin Lymphoma survivors
PROJECT ABSTRACT Hodgkin Lymphoma (HL) is a cancer whose principal therapies are associated with an increased risk for cardiopulmonary complications and cerebrovascular disease whe...
Enhancing intratumoral T cell infiltration by deliver of shCXCL5 in a Plectin targeted AAV to improve checkpoint blockade efficacy
ABSTRACT Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal disease and is expected to become the second leading cause of cancer-associated-death in the US by the year 2025...
The pro-metastatic role of androgen receptor in estrogen receptor mutated breast cancer
The five-year survival rate for metastatic breast cancer (MBC) remains less than 50% and nearly all patients eventually succumb to the disease; therefore, understanding pro-metasta...
Activation of protein kinases by proline hydroxylation
Project summary Eukaryotic protein kinases regulate important cellular processes through their ability to phosphorylate themselves and substrate proteins. One of the phosphorylatio...
Developing PARP-1 PET with companion tissue assay as a precision tool to guide PARPi therapy
Developing PARP-1 PET with companion tissue assay as a precision tool to guide PARPi therapy PROJECT SUMMARY When we give pharmaceuticals to patients with cancer, they deserve the...