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20,252 grants found
Showing 18,961 – 18,980 of 20,252 grants
Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer
Project Summary/Abstract Pancreatic cancer is the most deadly disease in human malignancies and effective treatment options are limited. Here, we hypothesize that Engrailed-1 (EN1)...
Rural Community Support for Colonoscopy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Appropriate screening can reduce CRC mortality. Colonoscopy, a pro...
Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain Tumors
Pediatric glioma is characterized by activation of the MAPK pathway, either through a tandem duplication of the BRAFA locus, or through point mutations (most frequently the V600E m...
Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer
Project Summary/Abstract Pancreatic cancer is the most deadly disease in human malignancies and effective treatment options are limited. Here, we hypothesize that Engrailed-1 (EN1)...
Rural Community Support for Colonoscopy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Appropriate screening can reduce CRC mortality. Colonoscopy, a pro...
Colorectal tumorigenesis on a cricket powder-based diet versus diets based on more typical protein sources
Although some debate continues over the precise strength of the scientific evidence, there remains a strong consensus that habitual consumption of processed meat is a prominent cau...
Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer
Project Summary/Abstract Pancreatic cancer is the most deadly disease in human malignancies and effective treatment options are limited.Here, we hypothesize that Engrailed-1 (EN1),...
Nutrition and Physical Activity Assessment Study - Assessment of Dietary Supplements
ABSTRACT We are responding to PA-20-227 ?Administrative Supplement for Research on Dietary Supplements? to support dietary supplement-related analysis of previously collected data...
Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain Tumors
Pediatric glioma is characterized by activation of the MAPK pathway, either through a tandem duplication of the BRAFA locus, or through point mutations (most frequently the V600E m...
Rural Community Support for Colonoscopy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Appropriate screening can reduce CRC mortality.Colonoscopy, a proc...
Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain Tumors
Pediatric glioma is characterized by activation of the MAPK pathway, either through a tandem duplication of the BRAFA locus, or through point mutations (most frequently the V600E m...
Rural Community Support for Colonoscopy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Appropriate screening can reduce CRC mortality. Colonoscopy, a pro...
Colorectal tumorigenesis on a cricket powder-based diet versus diets based on more typical protein sources
Although some debate continues over the precise strength of the scientific evidence, there remains a strong consensus that habitual consumption of processed meat is a prominent cau...
Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer
Project Summary/Abstract Pancreatic cancer is the most deadly disease in human malignancies and effective treatment options are limited. Here, we hypothesize that Engrailed-1 (EN1)...
Enhancing MAPK-targeted Therapy in PDX Models of BRAF-Mutant Pediatric Brain Tumors
Pediatric glioma is characterized by activation of the MAPK pathway, either through a tandem duplication of the BRAFA locus, or through point mutations (most frequently the V600E m...
Harnessing the EHR for the Delivery of Supportive Care in an Oncology Setting
Project Summary Symptom management and supportive care are essential to high-quality cancer care and optimal patient outcomes, but many barriers exist to their integration in routi...
Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis
Brain metastases account for decreased survival, increased morbidity, impaired cognition and poor quality of life for patients with lung cancer. Effective therapies for the treatme...
Adipokine Signaling as a Therapeutically Targetable Driver of Tumor Metabolism
Project Summary: The link between obesity and cancer is well-established epidemiologically, but poorly understood at a mechanistic level. Clear cell renal cell carcinoma (ccRCC) is...
Understanding and improving responses to adaptive NK cell therapy for leukemia and multiple myeloma
Project Summary Natural killer (NK) cells are potent, effector lymphocytes with the ability to kill malignant and virally infected cells by releasing lytic granules without the nee...
An integrated polymeric carrier for subunit cancer vaccines
PROJECT SUMMARY Cancer vaccines are a promising immuno-oncology approach that can elicit highly tumor-specific responses from the immune system, resulting in prolonged anti-cancer...